Physiologically based novel peroral modified release drug delivery system: Self-destructing hydrogel piston-pump

Resumen

Peroral modified drug delivery systems on the market release fue drug by either 0-order, 1º-order, square root oftime or mixed rate. This means that the drugis released mto the gastrointestinallumenin amounts being either constantper unit of time or decreasingwith time. However, physiologically absorption from the GI lumen gets slower and more difficult past the small intestme. A novel drug delivery system is described far 24 horus drug delivery which follows approximate 0-orden release throughout the small intestine, but releases increasing amounts of drug once in the colon ta compensate for increasingly more difficult absorption. Nearly constant steady state drug plasma concentrations are achieved . The novel drug delivery system is a two layered dosage form with an immediate release layer and a modified release layer. The latter ene is a hydrogel piston pump comprised of a drug core layer and a hydrogel swelling layer, embedded into a semipermeable shell by compression coating. The upper site of the shell has a release channel in the center.