Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex

Authors

  • Fredy Cruz-Bueza Complejo Hospitalario Luis Nicasio Sáenz, Policía Nacional del Perú. Lima, Peru https://orcid.org/0000-0002-0181-6728
  • Luis Inostroza-Ruiz Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica. Lima, Peru
  • Javier Córdova-Ramos Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica. Lima, Peru

DOI:

https://doi.org/10.15381/ci.v24i2.22521

Keywords:

sister chromatid exchange, antineoplastic drugs, occupational risk, healthcare personnel, genotoxicity

Abstract

Cytogenetic biomonitoring techniques allow early detection of exposure to genotoxic agents and the sister chromatid exchange assay (SCE) that was applied aimed to evaluate these effects in peripheral blood lymphocytes of health personnel exposed to antineoplastic drugs in a Hospital Complex of Lima. The exposed group was subdivided according to the proximity to the oncological preparations in: direct, intermediate and low contact, in addition there was a control group. The information was analyzed in the statistical program IBM SPSS 25.0. Statistically significant differences were found in the frequencies of exchanges in the groups of health personnel with direct and intermediate exposure compared to the control group (P<0.05), the comparative analysis between personnel with leave and the control group did not show significant differences. These findings allow evidence of a higher risk of genotoxicity for health personnel exposed to antineoplastic drugs.

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Published

2022-03-29

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Artículos Originales

How to Cite

1.
Cruz-Bueza F, Inostroza-Ruiz L, Córdova-Ramos J. Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex. Ciencia e investigación [Internet]. 2022 Mar. 29 [cited 2024 Jul. 17];24(2):15-20. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/22521