Aislamiento e identificación de alcaloides mutagénicos de las hojas de Ruta Graveolens L. por métodos espectroscópicos UV-IR

Abstract

The purpose of this research has been to iso late and identify the alkaloids from the leaves of Ruta graveolens L., and to relate their chemical structure with the mutagenic activity of the leaves, which was demonstrated in a previous report. It were isolated four alkaloids named "A", "1 ", "2" and "3" which were structurally elucidated by their melting point, chemical reactions and by UV and IR spectroscopy. The alkaloid "A" was identified as acridone alkaloid, and the alkaloid "1" and "2" were identified as furoquinoline alkaloids. The remaining one, alkaloid "3" was considered as quinolone alkaloid. Due to its high amount and chemical structure, the alkaloid "A" was considered as the main responsible of the mutagenic activity of the leaves of Ruta graveolens L., while alkaloids "1" and "2" probably do not participate in the mutagenicity of the extract owing to their amount. Finally, the alkaloid "3" was not considered in the mutagenicinity analysis on account of the absence of data about its structure.