Identification of producer enteroendocrine cells of glucagon like-peptide-1 (GLP-1) in the intestine of alpaca

Authors

  • César Hidalgo P. Laboratorio de Fisiología Animal, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima
  • María Vásquez C. Laboratorio de Fisiología Animal, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima
  • Boris Lira M. Laboratorio de Fisiología Animal, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima
  • José Rodríguez G. Centro de Investigaciones IVITA, Estación experimental El Mantaro, Universidad Nacional Mayor de San Marcos, Junín

DOI:

https://doi.org/10.15381/rivep.v26i3.11172

Keywords:

GLP-1, intestine, L cells, alpaca

Abstract

The aim of this study was to immunolocalize the distribution of producer enteroendocrine cells of glucagon-like peptide (GLP-1) on the epithelial intestine of alpacas. A total of 36 young (0-45 days old) and adult alpacas were used and distributed in seven age groups. The intestinal samples were processed by immunohistochemistry using an anti-GLP-1 monoclonal antibody. Positive cells were counted in 15 crypt-villus axis of each intestinal portion in each animal. In the group of newborns, the jejunum was the portion containing more L-cells, while other groups are in the jejunum and ileum. Regarding location, the duodenum showed a sustained increase of L-cells from day 8. The largest number of L cells in the jejunum and ileum occurred in the age groups of 0 and 8-45 days of age, respectively, while in the cecum and colon was observed in the group of adult animals. It is concluded that L-cells in alpacas are present from birth, mainly in the jejunum and ileum.

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RIVEP 26(3), 2015

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Published

2015-09-14

Issue

Vol. 26 No. 3 (2015)

Section

Artículos Primarios

License

Copyright (c) 2015 César Hidalgo P., María Vásquez C., Boris Lira M., José Rodríguez G.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

AUTHORS RETAIN THEIR RIGHTS:

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b. Authors retain their right to share, copy, distribute, perform and publicly communicate their article (eg, to place their article in an institutional repository or publish it in a book), with an acknowledgment of its initial publication in the Revista de Investigaciones Veterinarias del Perú (RIVEP).

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How to Cite

Hidalgo P., C., Vásquez C., M., Lira M., B., & Rodríguez G., J. (2015). Identification of producer enteroendocrine cells of glucagon like-peptide-1 (GLP-1) in the intestine of alpaca. Revista De Investigaciones Veterinarias Del Perú, 26(3), 373-380. https://doi.org/10.15381/rivep.v26i3.11172