Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies

Authors

  • Pamela Teibler Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste – UNNE
  • María Aguirre Facultad de Medicina, Universidad Nacional del Nordeste – UNNE
  • Tania Stoyanoff Facultad de Medicina, Universidad Nacional del Nordeste – UNNE
  • Sandra Núñez Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste – UNNE
  • Silvana Maruñak Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste – UNNE

DOI:

https://doi.org/10.15381/rivep.v29i2.14524

Keywords:

laminin 5, expression, biopsy, venom, culture, equine foot

Abstract

The aim of the present study was to study the expression of laminin 5 in equine foot biopsies precultured with venom of Bothrops diporus by histopathology and immunohistochemistry against untreated controls. The basal membranes of the laminae of the biopsies, as well as those of the interlamellar arterioles and veins, showed intense immunostaining of laminin 5 (L-5) in the control cultures; however, it was significantly lower in pre-cultured biopsies with the B. diporus venom concomitantly with the disruption of the typical laminar plate histoarchitecture. These results describe for the first time the normo-localization of L-5 in equine foot biopsies and the effect of the metalloproteinases, components of B. diporus venoms, both in the lamellar integrity and in the components of the vascularization.

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Published

2018-05-31

Issue

Vol. 29 No. 2 (2018)

Section

Artículos Primarios

License

Copyright (c) 2018 Pamela Teibler, María Aguirre, Tania Stoyanoff, Sandra Núñez, Silvana Maruñak

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

AUTHORS RETAIN THEIR RIGHTS:

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b. Authors retain their right to share, copy, distribute, perform and publicly communicate their article (eg, to place their article in an institutional repository or publish it in a book), with an acknowledgment of its initial publication in the Revista de Investigaciones Veterinarias del Perú (RIVEP).

c. Authors retain theirs right to make a subsequent publication of their work, to use the article or any part thereof (eg a compilation of his papers, lecture notes, thesis, or a book), always indicating the source of publication (the originator of the work, journal, volume, number and date).

How to Cite

Teibler, P., Aguirre, M., Stoyanoff, T., Núñez, S., & Maruñak, S. (2018). Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies. Revista De Investigaciones Veterinarias Del Perú, 29(2), 462-471. https://doi.org/10.15381/rivep.v29i2.14524