Comparison of the concentration of the transforming growth factor Beta 1 (TGF-β1) in synovial fluid of dogs with and without degenerative joint disease

Authors

  • Christof Fischer Wiethuchter Escuela de Medicina Veterinaria, Sede Concepción, Universidad Santo Tomás
  • Valentina Lepe Centro Veterinario Alemán Kleintierklinik, Concepción
  • Álvaro Opazo Escuela de Medicina Veterinaria, Sede Concepción, Universidad Santo Tomás
  • Álvaro Luzio Escuela de Medicina Veterinaria, Sede Concepción, Universidad Santo Tomás
  • Ignacio Troncoso Escuela de Medicina Veterinaria, Sede Concepción, Universidad Santo Tomás
  • Carolina Hernandez Escuela de Medicina Veterinaria, Sede Concepción, Universidad Santo Tomás

DOI:

https://doi.org/10.15381/rivep.v29i3.14758

Keywords:

ttransforming growth factor β1, synovial fluid, canines

Abstract

Degenerative joint disease (DJD) is a non-inflammatory pathology and characterized to be progressive, structural, and functional. The transforming growth factor Beta 1 (TGF-β1) is a regulatory cytokine participating in the production and deposition of extracellular matrix in various tissues, including joint cartilage. The aim of the present study was to compare the concentrations of transforming growth factor β1 in canine synovial fluid with (n=12) and without DJD (n=11), determined by an ELISA test. The mean concentration of TGB-β1 in dogs without DJD was 16.8 ± 7.1 ng/ml, while in dogs with DJD it was 10.3 ± 3.5 ng/ml (p <0.05).

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Published

2018-09-06

Issue

Vol. 29 No. 3 (2018)

Section

Artículos Primarios

License

Copyright (c) 2018 Christof Fischer Wiethuchter, Valentina Lepe, Álvaro Opazo, Álvaro Luzio, Ignacio Troncoso, Carolina Hernandez

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

AUTHORS RETAIN THEIR RIGHTS:

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b. Authors retain their right to share, copy, distribute, perform and publicly communicate their article (eg, to place their article in an institutional repository or publish it in a book), with an acknowledgment of its initial publication in the Revista de Investigaciones Veterinarias del Perú (RIVEP).

c. Authors retain theirs right to make a subsequent publication of their work, to use the article or any part thereof (eg a compilation of his papers, lecture notes, thesis, or a book), always indicating the source of publication (the originator of the work, journal, volume, number and date).

How to Cite

Fischer Wiethuchter, C., Lepe, V., Opazo, Álvaro, Luzio, Álvaro, Troncoso, I., & Hernandez, C. (2018). Comparison of the concentration of the transforming growth factor Beta 1 (TGF-β1) in synovial fluid of dogs with and without degenerative joint disease. Revista De Investigaciones Veterinarias Del Perú, 29(3), 729-733. https://doi.org/10.15381/rivep.v29i3.14758