Effect of platelet-rich plasma on skin flaps in rabbits

Authors

  • Catherine Aragón-Urrego Facultad de Medicina Veterinaria y Zootecnia, Universidad del Tolima, Ibagué, Tolima
  • Irma Ximena Barbosa Facultad de Medicina Veterinaria y Zootecnia, Universidad del Tolima, Ibagué, Tolima
  • Omar Leonardo Aristizabal Facultad de Medicina Veterinaria y Zootecnia, Universidad del Tolima, Ibagué, Tolima

DOI:

https://doi.org/10.15381/rivep.v29i4.15351

Keywords:

rabbit, autologous platelets concentrate, skin flap, wound healing

Abstract

Autologous platelet concentrates (APC) has been used as an accelerator of cutaneous healing in veterinary medicine. The aim of this study was to evaluate the effect of an APC on skin flaps in rabbits (Oryctolagus cuniculus). Ten New Zealand male rabbits were randomly divided into a control group and an APC group. A rotating cutaneous flap was made in the thoraco-dorsal region of the right thoracic limb of the rabbits. Half of the rabbits received APC infiltrated under the flap. Biopsies were taken from the union of the flap with the recipient bed at 3, 7, 14, and 21 days post-surgery. The histological analysis of the inflammatory infiltrate was made, and the proliferation of fibroblasts and type of collagen formed was determined. A significant difference was observed in the neutrophil count, macrophages and fibroblasts. The histological analysis showed that a single application of CAP does not reduce the healing time in skin flaps; however, it promotes the formation of blood vessels and reduces the inflammatory infiltrate in rabbits throughout experimental time.

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Published

2018-11-25

Issue

Vol. 29 No. 4 (2018)

Section

Artículos Primarios

License

Copyright (c) 2018 Catherine Aragón-Urrego, Irma Ximena Barbosa, Omar Leonardo Aristizabal

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

AUTHORS RETAIN THEIR RIGHTS:

a. Authors retain their trade mark rights and patent, and also on any process or procedure described in the article.

b. Authors retain their right to share, copy, distribute, perform and publicly communicate their article (eg, to place their article in an institutional repository or publish it in a book), with an acknowledgment of its initial publication in the Revista de Investigaciones Veterinarias del Perú (RIVEP).

c. Authors retain theirs right to make a subsequent publication of their work, to use the article or any part thereof (eg a compilation of his papers, lecture notes, thesis, or a book), always indicating the source of publication (the originator of the work, journal, volume, number and date).

How to Cite

Aragón-Urrego, C., Barbosa, I. X., & Aristizabal, O. L. (2018). Effect of platelet-rich plasma on skin flaps in rabbits. Revista De Investigaciones Veterinarias Del Perú, 29(4), 1184-1194. https://doi.org/10.15381/rivep.v29i4.15351