Optimization of antibiotic dosing regime through pharmacokinetics/ pharmacodynamics integration: a review

Authors

  • Larissa Alexsandra Felix Universidade Federal de Lavras, Faculdade de Zootecnia e Medicina Veterinária, Lavras, Minas Gerais, Brasil
  • Beatriz Monte Egito Universidade Federal de Lavras, Faculdade de Zootecnia e Medicina Veterinária, Lavras, Minas Gerais, Brasil https://orcid.org/0000-0002-3019-0824
  • Gonzalo Suárez Universidad de la República, Facultad de Veterinaria, Montevideo, Uruguay https://orcid.org/0000-0003-2452-3546
  • Marcos Ferrante Universidade Federal de Lavras, Faculdade de Zootecnia e Medicina Veterinária, Lavras, Minas Gerais, Brasil

DOI:

https://doi.org/10.15381/rivep.v35i3.25975

Keywords:

antibiotic therapy, pharmacometrics, dosage regimen, antimicrobial resistance

Abstract

The indiscriminate use of antimicrobials led to the emergence of antimicrobial resistance (AMR), so the rational use of these medications becomes extremely necessary. Thus, an alternative is the use of pharmacokinetic/pharmacodynamic (PK/PD) integration, a tool used in human and veterinary medicine, to determine dosing regimen optimization. Optimizing the dosage regimen makes it possible to establish therapies with greater precision and probability of clinical success, in addition to minimizing toxicity and the spread of antimicrobial resistance. PK/PD integration studies are included in the European Medicines Agency (EMA) guidelines for evaluating medical products; however, this tool needs to be more widespread. Additionally, in 2015, the World Health Organization (WHO) established optimizing antimicrobial doses as one of the five critical points to help reduce the spread of AMR, so PK/PD integration can be used for this purpose. Therefore, this review aimed to elucidate the aspects of PK/PD integration in the selection and optimization of dosing regimens to increase awareness of their development and use by veterinary practitioners.

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Published

2024-06-28

Issue

Vol. 35 No. 3 (2024)

Section

Artículo de revisión

License

Copyright (c) 2024 Larissa Alexsandra Felix, Beatriz Monte Egito, Gonzalo Suárez, Marcos Ferrante

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

AUTHORS RETAIN THEIR RIGHTS:

a. Authors retain their trade mark rights and patent, and also on any process or procedure described in the article.

b. Authors retain their right to share, copy, distribute, perform and publicly communicate their article (eg, to place their article in an institutional repository or publish it in a book), with an acknowledgment of its initial publication in the Revista de Investigaciones Veterinarias del Perú (RIVEP).

c. Authors retain theirs right to make a subsequent publication of their work, to use the article or any part thereof (eg a compilation of his papers, lecture notes, thesis, or a book), always indicating the source of publication (the originator of the work, journal, volume, number and date).

How to Cite

Alexsandra Felix, L., Monte Egito, B., Suárez, G., & Ferrante, M. (2024). Optimization of antibiotic dosing regime through pharmacokinetics/ pharmacodynamics integration: a review. Revista De Investigaciones Veterinarias Del Perú, 35(3), e25975. https://doi.org/10.15381/rivep.v35i3.25975