Genetic variability of Plasmodium vivax and patterns of recurrence in asymptomatic malaria at Mazan, Iquitos, Peru
DOI:
https://doi.org/10.15381/anales.v73i4.1026Keywords:
Malaria/vivax, plasmodium vivax, genotypeAbstract
Plasmodium vivax displays a high genetic variability for recurrent episodes of illness. Objectives: To determine the genetic variability of P. vivax and patterns of recurrence in asymptomatic malaria. Design: Descriptive analytical. Setting: Laboratory of Infectious Disease Research, Universidad Peruana Cayetano Heredia. Population: Individuals from Mazan, Iquitos, Peru, a malaria endemic region. Intervention: Between June 2006 and November 2008, 222 individuals were analyzed with two sequential blood samples. Main outcome measures: Identification of P. vivax, genotyping based on gene pvmsp3-α, genetic variability of P. vivax and patterns of recurrence. Results: First evaluation: Positive for P. vivax 191/222 (86%), P. falciparum 2/222 (0.9%), mixed infection 21/222 (9.5%) and negative 8/222 (3.6%). Second evaluation: 180/191 (94.2%) remained positive for P. vivax. Genotyping by nested PCR and enzymatic digestion showed polyclonal haplotypes in 17/180 (9.4%) and monoclonal in 163/180 (90.6%). Different haplotypes (reinfection) were observed in 88/180 (48.9%) and identical haplotypes (relapse) in 75/180 (41.7%). Conclusions: There was P. vivax high genetic variability and patterns of malaria recurrence based on genotyping showed differences between reinfection and relapse in asymptomatic individuals in Mazan, Iquitos.Downloads
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2012-12-31
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Copyright (c) 2012 Edward Valencia Ayala, Maritza Calderón Sánchez, Manuel Martín Fasabi Espinar
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Valencia Ayala E, Calderón Sánchez M, Fasabi Espinar MM. Genetic variability of Plasmodium vivax and patterns of recurrence in asymptomatic malaria at Mazan, Iquitos, Peru. An Fac med [Internet]. 2012 Dec. 31 [cited 2024 Aug. 16];73(4):285-92. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1026