Antiinflammatory and antioxidant effects of Jungia rugosa Less (matico de puna) leaves' flavonoids in rats

Authors

  • Edwin Enciso Escuela de Posgrado, Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos. Lima, Perú
  • Jorge Arroyo Laboratorio de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú

DOI:

https://doi.org/10.15381/anales.v72i4.1074

Keywords:

Jungia rugosa Less, flavonoid, anti-inflammatory and antioxidant activity

Abstract

Objectives: To determine anti-inflammatory and antioxidant activities of Jungia rugosa Less leaves flavones’ fraction. Design: Experimental. Setting: Faculties of Medicine and Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru. Biological material: Flavones fraction extracted from Jungia rugosa Less leaves and rats. Interventions: Jungia rugosa Less leaves collected in Condorcunca’s hill at 3 500 m.a.s.l., Quinua district, Ayacucho department. The anti-inflammatory activity was assessed in vivo in carrageenan-induced paw edema model and 1, 6 interleukins serum levels and C reactive protein (CRP) were measured in blood; granuloma was induced according to Sedwicks and studied by histopathology. The antioxidant effect was investigated in vitro by 1,1- diphenyl-2-picrylhydrazyl (DPPH) radical neutralization. Main outcome measures: Anti-inflammatory and antioxidant effects. Results: Inflammation reduced in 43,8% and 1,6 interleukins and CRP levels decreased respectively 80%, 90% and 78% compared to control, in dose-dependent effect (p<0,05), with 97,7% DPPH radicals inhibition. Conclusions: Flavones fraction extracted from Jungia rugosa Less leaves is anti-inflammatory and antioxidant.

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Published

2011-12-30

Issue

Vol. 72 No. 4 (2011)

Section

Trabajos originales

License

Copyright (c) 2011 Edwin Enciso, Jorge Arroyo

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How to Cite

1.
Enciso E, Arroyo J. Antiinflammatory and antioxidant effects of Jungia rugosa Less (matico de puna) leaves’ flavonoids in rats. An Fac med [Internet]. 2011 Dec. 30 [cited 2024 Jul. 3];72(4):231-7. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1074