The role of endothelium in pregnancy induced hypertension: alterations common with those of atherosclerosis?

Authors

  • Patricio López-Jaramillo Dirección de Investigaciones, Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Santander, Colombia. Instituto Masira, Facultad de Medicina, Universidad de Santander (UDES), Bucaramanga, Santander, Colombia
  • Katherine Sotomayor Rubio Dirección de Investigaciones, Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Santander, Colombia
  • Arístides Sotomayor-Rubio Dirección de Investigaciones, Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Santander, Colombia
  • Cristina López López Facultad de Medicina, Universidad Autónoma de Bucaramanga (UNAB), Santander, Colombia

DOI:

https://doi.org/10.15381/anales.v75i4.10858

Keywords:

Vascular endothelium, pregnancy, hypertension, metabolic syndrome, preeclampsia, atherosclerosis, cardiovascular disease

Abstract

Pregnancy induced hypertension, called preeclampsia (PE) when accompanied by proteinuria, is an alteration that occurs in the second trimester of pregnancy and is characterized by presence of hypertension and proteinuria. Adaptative physiologic changes occur during normal pregnancy including insulin-resistance (IR), hyperlipidemia, hypercoagulability, inflammation, and hyperdynamic circulatory status. Expression of these changes is exaggerated in women developing PE. These alterations are also present in the metabolic syndrome (MS) risk factors cluster, which is in turn a risk factor for developing type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). In this review endothelial dysfunction is proposed as a common alteration that explains the presence of these two common diseases in Latin America.

Author Biography

  • Patricio López-Jaramillo, Dirección de Investigaciones, Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Santander, Colombia. Instituto Masira, Facultad de Medicina, Universidad de Santander (UDES), Bucaramanga, Santander, Colombia

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    Encargado del Área de Telemática de la Biblioteca San Fernando

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Published

2014-12-31

Issue

Vol. 75 No. 4 (2014)

Section

Simposio función endotelial

License

Copyright (c) 2014 Patricio López-Jaramillo, Katherine Sotomayor Rubio, Arístides Sotomayor-Rubio, Cristina López López

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How to Cite

1.
López-Jaramillo P, Sotomayor Rubio K, Sotomayor-Rubio A, López López C. The role of endothelium in pregnancy induced hypertension: alterations common with those of atherosclerosis?. An Fac med [Internet]. 2014 Dec. 31 [cited 2024 Jul. 17];75(4):361-6. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/10858