The efficiency of free PSA index in the diagnosis of prostate cancer

Authors

  • José Ortiz '
  • Emilio Almoguer '

DOI:

https://doi.org/10.15381/anales.v76i1.11072

Keywords:

Prostate specific antigen, level of free PSA, prostate cancer

Abstract

Determining the efficiency of testing free PSA index in the diagnosis of prostate cancer. Design: Retrospective study. Location: Edgardo Rebagliati Martins National Hospital, EsSalud, Lima, Peru. Participants: Patients undergoing prostate biopsy. Interventions: Collection of data from 371 patients undergoing prostate biopsy -104 cases of prostate cancer and 267 cases of benign hyperplasia próstata-, by review of hospital medical records and review of pathological studies. Main outcome measures: Sensitivity, specificity, positive predictive value, negative predictive value, ROC curve (receiver operating characteristic) and area under the ROC curve (AUC) curve. Results: The rate of free PSA with the cutoff used in clinical practice of 0.20 showed a sensitivity of 0.85, specificity of 0.51, positive predictive value of 0.41, negative predictive value 0.90. The cutoff with a sensitivity of 0.95 was obtained 0.28. The area under the ROC curve was 0.78. Conclusions: The test demonstrated free PSA index improving the specificity of total PSA to avoid unnecessary biopsies. Be advisable to raise the cutoff of 0.20 used to increase the sensitivity of the test to 95%, to avoid the loss of detected cases of prostate cancer.

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Published

2015-03-31

Issue

Vol. 76 No. 1 (2015)

Section

Artículo Original

License

Copyright (c) 2015 José Ortiz, Emilio Almoguer

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How to Cite

1.
Ortiz J, Almoguer E. The efficiency of free PSA index in the diagnosis of prostate cancer. An Fac med [Internet]. 2015 Mar. 31 [cited 2024 Jul. 17];76(1):27-32. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/11072