Hepatoprotective effect of atomized hydroethanolic extract from Andean purple (Zea mays L.) in induced hepatic injury in rats.
DOI:
https://doi.org/10.15381/anales.v76i2.11136Keywords:
Zea mays L, liver injury, hepatomegaly, medicinal plant.Abstract
Objectives: To evaluate the hepatoprotector effect of hydroalcoholic extract atomized of Zea mays against hepatic injuries induced in rats. Design: Experimental. Institution: Laboratory of Experimental Pharmacology, Faculty of Human Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Hydroethanolic extract atomized of purple corn (EAM). Interventions: To six groups of male rats (n = 10, for each group) phenobarbital 0.5 g/L in drinkable water ad libitum was administered for 15 days, followed by carbon tetrachloride 0.2 mL/kg p.o. The experimental design was a follow: G1: normal; G2: CCl4 0.2 mL/kg (T); G3:T+ silimarina 25 mg/kg; G4: T+ EAM 500 mg/kg; G5: T + EAM 1 000 mg/kg; G6 T + EAM 2 000 mg/kg. Main outcome measures: Hepatic profile, reactive species to thiobarbituric acid (TBARS), liver index, and histological observation. Results: Significant increase (p<0.05) in ALT activity was observed between group G2 in comparison to groups G3 and G4 (p<0,001). There was significant decrease (p < 0.05) of alkaline phosphatase (AP) in group G2 with respect to G1. TBARS level was less in the group that received 1 000 mg/kg of EAM regarding to control. HDL-C and triglycerides activities did not show significant differences. Reduction in 60% of hepatic injury was observed, evidencing less damage of the hepatocyte by histological study. Conclusions: The purple corn atomized hydroethanolic extract at 1 000 mg/kg dose decreased induced hepatic injuries in rats.Downloads
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2015-06-15
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Copyright (c) 2015 Renán Hañari Quispe, Jorge Arroyo, Oscar Herrera Calderón, Hernán Herrera Moran
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Hañari Quispe R, Arroyo J, Herrera Calderón O, Herrera Moran H. Hepatoprotective effect of atomized hydroethanolic extract from Andean purple (Zea mays L.) in induced hepatic injury in rats. An Fac med [Internet]. 2015 Jun. 15 [cited 2024 Aug. 16];76(2):123-8. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/11136