Oxidative stress markers in mild hypertension

Authors

  • Raquel Oré Centro de Investigación de Bioquímica y Nutrición. Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú
  • Rubén Valdivieso Centro de Investigación de Bioquímica y Nutrición. Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú
  • Silvia Suárez Centro de Investigación de Bioquímica y Nutrición. Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú
  • Doris Huerta Centro de Investigación de Bioquímica y Nutrición. Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú
  • Marco Núñez Centro de Investigación de Bioquímica y Nutrición. Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú
  • Jorge Durand New York University. New York, USA

DOI:

https://doi.org/10.15381/anales.v68i4.1202

Keywords:

Oxidative stress, hypertension, superoxide dismutase, selenium, magnesium, zinc, lipid peroxidation

Abstract

Introduction: Hypertension is a cardiovascular risk factor and the initial mechanism is unknown in 90% of the cases. Currently hypertension is considered a syndrome with metabolic and structural abnormalities where oxygen reactive species (ORS) play a preponderant pathophysiological role. Objective: To determine zinc, selenium and magnesium serum levels in hypertensive and normotensive subjects, and to measure superoxide dismutase (SOD) activity and thiobarbituric acid reactive substances (TBARS) levels in both groups. Design: Analytical observational, case-control study. Setting: Biochemistry and Nutrition Research Center, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Normotensive and mild hypertensive patients blood samples. Interventions: Blood samples from 20 normotensive subjects and 20 patients with mild hypertension aged 50 to 60 years were obtained after 12-hour fasting. We studied serum and whole blood. Main outcome measures: Serum determination of TBARS and oligoelements (Zn and Mg), measurement of SOD erythrocytic activity. Results: In the hypertensive group we obtained significant increase in magnesium and TBARS, and significant decrease in zinc and SOD activity. Conclusions: We demonstrated the occurrence of oxidative stress in mild hypertensive patients. Hypermagnesemia could be explained by blood elements injury.

Downloads

Published

2007-12-31

Issue

Vol. 68 No. 4 (2007)

Section

Trabajos originales

License

Copyright (c) 2007 Raquel Oré, Rubén Valdivieso, Silvia Suárez, Doris Huerta, Marco Núñez, Jorge Durand

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Those authors who have publications with this magazine accept the following terms:

  1. Authors will retain their copyrights and guarantee the journal the right of first publication of their work, which will be simultaneously subject to Creative Commons Attribution License that allows third parties to share the work as long as its author and its first publication this magazine are indicated.
  2. Authors may adopt other non-exclusive licensing agreements for the distribution of the version of the published work (eg, deposit it in an institutional electronic file or publish it in a monographic volume) provided that the initial publication in this magazine is indicated.
  3. Authors are allowed and recommended to disseminate their work over the Internet (eg: in institutional telematic archives or on their website) before and during the submission process, which It can produce interesting exchanges and increase quotes from the published work. (See El efecto del acceso abierto ).

How to Cite

1.
Oré R, Valdivieso R, Suárez S, Huerta D, Núñez M, Durand J. Oxidative stress markers in mild hypertension. An Fac med [Internet]. 2007 Dec. 31 [cited 2024 Jul. 2];68(4):351-5. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1202