Phenolic compounds from Bidens pilosa methanolic fraction on induced gastric neoplasia in rats

Authors

  • Jorge Arroyo Instituto de Investigaciones Clínicas. Facultad de Medicina, UNMSM. Lima, Perú
  • Pablo Bonilla Instituto de Ciencias Farmacéuticas y Recursos Naturales. Facultad de Farmacia y Bioquímica, UNMSM. Lima, Perú
  • Ernesto Ráez Instituto de Patología. Facultad de Medicina, UNMSM. Lima, Perú
  • Silvia Suárez Centro de Investigación de Bioquímica y Nutrición. Facultad de Medicina, UNMSM. Lima, Perú
  • Robert Palomino Sección de Farmacología. Facultad de Medicina, UNMSM. Lima, Perú
  • Segundo Terán Sección de Farmacología. Facultad de Medicina, UNMSM. Lima, Perú
  • Aníbal Villarreal Sección de Farmacología. Facultad de Medicina, UNMSM. Lima, Perú
  • Manuel Marin Instituto de Ciencias Biológicas Antonio Raymondi. Facultad de Ciencias Biológicas, UNMSM. Lima, Perú
  • Julio Chenguayén Facultad de Farmacia y Bioquímica, UNMSM. Lima, Perú
  • Hugo Justil Facultad de Farmacia y Bioquímica, UNMSM. Lima, Perú

DOI:

https://doi.org/10.15381/anales.v68i2.1220

Keywords:

Stomach neoplasms, research, phenols, bioflavonoids, plant extracts

Abstract

Objective: To determine the influence of both the ethanolic extract and the methanolic fraction containing phenolic and flavonoids compounds of Bidens pilosa L whole plant on gastric cancer induced in rats with N-nitroso-N-methylurea (NMU). Design: Experimental. Setting: Instituto de Investigaciones ClínicasBioterio, Facultad de Medicina UNMSM. Biologic material: Holtzmann male albino rats. Interventions: Following Ferraz de Souza et al., 2002, we had a normal control group, a group with NMU and NMU groups plus treatments with ethanolic extract and methanolic fraction at 300 mg/kg doses. For statistical significance we considered p<0,05. Main outcome measures: Progresion of gastric neoplasia induced in rats. Results: Indicate dysplasia and initial stages of carcinoma in the rats stomachs, which was less evident in the animals with treatment, being better the group that received the methanolic fraction. The marker of oxidative stress decreased in the groups that received treatment with the plant, being better the methanolic fraction. We observed less amount of micronuclei (genotoxicity) in the animals that received treatment. Conclusions: In experimental conditions the ethanolic extract and methanolic fraction delayed the advance of gastric cancer induced in rats.

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Published

2007-06-18

Issue

Vol. 68 No. 2 (2007)

Section

Trabajos originales

License

Copyright (c) 2007 Jorge Arroyo, Pablo Bonilla, Ernesto Ráez, Silvia Suárez, Robert Palomino, Segundo Terán, Aníbal Villarreal, Manuel Marin, Julio Chenguayén, Hugo Justil

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How to Cite

1.
Arroyo J, Bonilla P, Ráez E, Suárez S, Palomino R, Terán S, et al. Phenolic compounds from Bidens pilosa methanolic fraction on induced gastric neoplasia in rats. An Fac med [Internet]. 2007 Jun. 18 [cited 2024 Jul. 3];68(2):105-12. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1220