Soya effects on post menopausal endometrial mucosa

Authors

  • Delia Jara Instituto de Patologia. Facultad de Medicina, UNMSM. Lima, Perú
  • Victoria Valer Instituto de Patologia. Facultad de Medicina, UNMSM. Lima, Perú
  • Inés León Instituto de Patologia. Facultad de Medicina, UNMSM. Lima, Perú

DOI:

https://doi.org/10.15381/anales.v67i2.1247

Keywords:

Soybeans, postmenopause, menopause, endometrium

Abstract

Objective: To determine endometrial morphology and estrogen receptors expression changes in post menopausal women following oral soya treatment. Design: Descriptve, observational, longitudinal and prospective study. Setting: Pathology Institute, San Marcos National Major University. Patients: Twenty-two post menopausal women treated with soya. Interventions: Histological and immunohistochemical studies were done in endometrium aspiration biopsies before and after 6 months treatment with 60 g oral soya per day. Main outcome measures: Endometrium histology and estrogen and progesterone receptors expression changes. Results: Age ranged between 46 and 65 years, 53 years average. There was apparent vasomotor symptoms improvement. Endometrium before soya treatment was atrophic in 19 patients (86%) and inactive in 3 (14%). Following soya treatment 17 (77,3%) persisted atrophic, 4 (18,2%) were inactive and one became proliferative. Estrogen receptor expression was negative before soya treatment in 19 patients (86%) and 16 (76%) remained negative following treatment. Conclusions: Post menopausal women treated with soya during 6 months showed persistence of atrophic endometrium and negative expression for estrogen receptors

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Published

2006-06-19

Issue

Vol. 67 No. 2 (2006)

Section

Trabajos originales

License

Copyright (c) 2006 Delia Jara, Victoria Valer, Inés León

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How to Cite

1.
Jara D, Valer V, León I. Soya effects on post menopausal endometrial mucosa. An Fac med [Internet]. 2006 Jun. 19 [cited 2024 Jul. 3];67(2):101-7. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1247