An update on diagnosis of coeliac disease

Authors

  • Raúl Emilio Real Delor Jefe del Departamento de Medicina Interna, Hospital Nacional, Itauguá, Paraguay

DOI:

https://doi.org/10.15381/anales.v77i4.12657

Keywords:

Celiac Disease, IgA Tissue Transglutaminase Antibody, Upper Gastrointestinal Endoscopy, Major Histocompatibility Antigen, Gluten.

Abstract

Celiac disease (CD) is a multisystem autoimmune condition induced by gluten in genetically susceptible individuals. The classical clinical presentation is the chronic diarrhea syndrome although there are atypical and silent forms, which may lead to diagnostic problems. Diagnosis is based on the detection of various autoantibodies, especially against tissue transglutaminase IgA, although the gold standard is the pathological examination of duodenal biopsies obtained by upper endoscopy. The absence of the HLA gene is a test used to rule CD. The response to gluten-free diet confirms this condition, which if not promptly diagnosed and properly treated can lead to serious complications.

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Published

2016-12-16

Issue

Vol. 77 No. 4 (2016)

Section

Artículos de Revisión

License

Copyright (c) 2016 Raúl Emilio Real Delor

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How to Cite

1.
Real Delor RE. An update on diagnosis of coeliac disease. An Fac med [Internet]. 2016 Dec. 16 [cited 2024 Jul. 17];77(4):397-402. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/12657