Citotoxic effect of Physalis peruviana (capuli) in colon cancer and chronic myeloid leukemia
DOI:
https://doi.org/10.15381/anales.v67i4.1309Keywords:
Physalis peruviana, antibody-dependent cell citotoxicity, citotoxicity immunologic, colonic neoplasmsAbstract
Objective: To determine Physalis peruviana cytotoxic activity in the colo-205 (colon cancer) and K562 (chronic mieloid leukemia) cell lines. Design: Experimental study. Setting: San Marcos Major National University Pharmacology Department and Cayetano Heredia Peruvian University Sciences and Phylosophy Faculty laboratories. Materials: The lines colo-205, K562 and 3T3 cell lines, P. peruviana ethanolic leave and stem extracts, and 5-FU. Interventions: Colo-205, K562 and 3T3 (normal mouse fibroblasts) cell lines were exposed to P. peruviana ethanolic leave and stem extracts, and 5-FU was used as positive control. Main outcome measures: Physalis peruviana cytotoxic activity in the colo-205 and K562 cell lines. Results: The leaves and stems Physalis peruviana IC50 in μg/ml in the colo-205 and K562 cell lines was respectively 1,93 (r=-0,89 p<0,01) and 0,84 (r=-0,91 p<0,01) for colo-205, 2,42 (r=-0,98 p<0,005) and 2,1 (r=-0.98, p<0.005) for K562, and 2,67 (r=-0,98 p<0,005) and 4,59 (r=- 0,96 p<0,005) for 3T3. The 5-FU IC50 was 3,57 (r=-0,96 p<0,005), 15,95 (r=-0,97 p<0,025), and 0,51 (r=-0,88 p =0,01) for colo- 205, K562 and 3T3 respectively. The leaves and stems extracts and of 5-FU selectivity index were respectively 1,38, 5,46, 0,14 for colo-205 and 1,10, 2,18, 0,032 for K562. Conclusions: The P. peruviana leaves and steams ethanolic extracts were more cytotoxic than 5-FU in the colo-205 and K562 cell lines. Furthermore the P. peruviana cytotoxic effects were less than 5- FU for 3T3 cells.Downloads
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2006-12-29
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Copyright (c) 2006 David Zavala, Angel Quispe, Margarita Posso, José Rojas, Abraham Vaisberg
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Zavala D, Quispe A, Posso M, Rojas J, Vaisberg A. Citotoxic effect of Physalis peruviana (capuli) in colon cancer and chronic myeloid leukemia. An Fac med [Internet]. 2006 Dec. 29 [cited 2024 Jul. 17];67(4):283-9. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1309