HER-2 positive breast carcinoma associated pathological characteristics
DOI:
https://doi.org/10.15381/anales.v66i2.1355Keywords:
Breast neoplasms, Paget's disease mammary, protooncogene proteins HER-2Abstract
Objective: To determine the prevalence and associated characteristics of HER-2 overexpression in infiltrative primary breast cancer. Materials and Methods: From October through December 2003 and from May through December 2004, 274 cases of infiltrative primary breast carcinoma were studied and pathological characteristics correlation with HER-2 overexpression 3+ was determined at Edgardo Rebagliati Martins National Hospital’s Pathological Anatomy Department. Results: Three plus HER-2 overexpression was found in 64 (23,4%) cases, 2+ in 9 (3,3%) and negative (1+ or 0) in 201 (73,4%) cases. The non-specified infiltrative ductal histology type was present in 211 (77%) cases, and the infiltrative lobulillar in 27 (9,9%). We determined associated 3+ overexpression in non-specified infiltrative ductal carcinoma (p=0,0001), nipple Paget’s disease (p <0,0001), and when estrogen receptors tumor expression was absent (p <0,0001). Only the absence of estrogen receptors expression was an independent associated characteristic (p <0,0001). Conclusions: The prevalence of 3+ overexpression occurred in 23,4% of the cases, and the associated characteristics were the non-specified infiltrative ductal histology type, nipple Paget’s disease, and the absence of estrogen receptors expression.Downloads
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2005-06-13
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Copyright (c) 2005 Carlos González-Müller
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González-Müller C. HER-2 positive breast carcinoma associated pathological characteristics. An Fac med [Internet]. 2005 Jun. 13 [cited 2024 Aug. 17];66(2):89-9. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1355