Preimplantational embryo development in in vitro fertilization cycles with oocyte donation and genetic studies
DOI:
https://doi.org/10.15381/anales.v78i3.13762Keywords:
Embryo development, Genetics, In vitro Fertilization, Preimplantational Genetic Study.Abstract
Introduction: Preimplantational genetic studies are used to achieve a better implantation rate and live birth, as well as to decrease the abortion rate; these techniques should be evaluated. Objective: To evaluate preimplantational embryo development in donor oocyte in vitro fertilization cycles with genetic studies. Design: Retrospective cohort study. Setting: Pranor Laboratory, 2008-2013. Material: In vitro fertilization with ovodonation (IVF-OD) cycles. Interventions.: 2 077 cycles of IVF-OD were evaluated, separated in 3 cohorts: Cohort 1, cycles with embryo biopsy on day 3, by means of an incision in the zona pellucida (ZP), for excision of a blastomer (n = 527); Cohort 2, cycles with a laser incision at day 4 of embryo development, for biopsy of the trophoblast in the blastocyst stage (n = 131) and; cohort 3, FIV-OD cycles without any intervention (n = 1 419). Main outcome measures: Fertilization rate, blastulation rate. Results: There was no difference in the fertilization rate of the three groups studied (75.0%, 74.6% and 75.9% respectively, p = 0.31). Blastulation rate in cohort 1, was 42.5%, whereas cohort 3 was 47% (RR = 1.085, CI = 1.051-1.120; p <0.0001). In addition, cohort 2 had 51.9%, with statistical significance, which prevents from non-blastulation risk compared with cohort 3 (RR = 0.906; IC = 0.851-0.965; p = 0.0017). Conclusions: Preimplantational embryo development would improve blastocyst formation when laser is performed on day 4. Further studies are needed to confirm our results.Downloads
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2017-11-30
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Copyright (c) 2017 Pamela Villanueva, Jimmy Portella, Rosmary López, Nathaly Chávez, Amalia Villalobos, Luis Noriega-Hoces, Luis Guzmán
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Villanueva P, Portella J, López R, Chávez N, Villalobos A, Noriega-Hoces L, et al. Preimplantational embryo development in in vitro fertilization cycles with oocyte donation and genetic studies. An Fac med [Internet]. 2017 Nov. 30 [cited 2024 Jul. 17];78(3):298-302. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/13762