Distribution of plasma homocysteine, folate and B-12 vitamin in Lima, Peru's young adults
DOI:
https://doi.org/10.15381/anales.v65i2.1396Keywords:
Homocysteine, folic acid, vitamin B-12, fluorescence polarization immunoassayAbstract
Objective: To describe the distribution of plasma homocysteine, folic acid, B-12 vitamin concentrations among students living in the city of Lima, Peru. Material and Methods: Transversal cohort study of 65 young adults between 18 and 30 year-old. The plasma homocysteine concentration was determined by fluorescence polarization inmunoassay FPIA from Abbott Laboratories, folic acid by ionic capture and vitamin B-12 by enzimatic assay. Results: The distribution of homocysteine values ranged from 1,40 to 24,04 mmol /L; geometric mean homocysteine 8,32±5,46, median 7,76 mmol/L. Homocysteine geometric means were significantly higher (p=0,005) in men (9,97±4,81 mmol/L) than in women (7,35±2,03 mmol/L). Plasma homocysteine level was significantly correlated with folic acid plasma level (r=-0,329, p=0,007) but not with B-12 vitamin. However, plasma homocysteine level was correlated with body mass index (r=0,391; p=0,001). Conclusions: The distribution of homocysteine levels in our sample is within the reference range already reported. However, there was a complete shift of the homocysteine distribution curve towards lower values. Plasma folic acid levels may be a determinant factor in the variation of homocysteine levels.Downloads
Published
2004-06-14
Issue
Section
Trabajos originales
License
Copyright (c) 2004 MERCEDES SOBERÓN, ADA CHARAJA, YSELA AGÜERO, ROSA ORIONDO, MIGUEL SANDOVAL, MARCO NÚÑEZ
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Those authors who have publications with this magazine accept the following terms:
- Authors will retain their copyrights and guarantee the journal the right of first publication of their work, which will be simultaneously subject to Creative Commons Attribution License that allows third parties to share the work as long as its author and its first publication this magazine are indicated.
- Authors may adopt other non-exclusive licensing agreements for the distribution of the version of the published work (eg, deposit it in an institutional electronic file or publish it in a monographic volume) provided that the initial publication in this magazine is indicated.
- Authors are allowed and recommended to disseminate their work over the Internet (eg: in institutional telematic archives or on their website) before and during the submission process, which It can produce interesting exchanges and increase quotes from the published work. (See El efecto del acceso abierto ).
How to Cite
1.
SOBERÓN M, CHARAJA A, AGÜERO Y, ORIONDO R, SANDOVAL M, NÚÑEZ M. Distribution of plasma homocysteine, folate and B-12 vitamin in Lima, Peru’s young adults. An Fac med [Internet]. 2004 Jun. 14 [cited 2024 Jul. 17];65(2):89-96. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1396