INDUCTION OF GASTRIC MUCUS BY DRAGON’S BLOOD (Croton palanostigma)

Authors

  • MIGUEL SANDOVAL Centro de Investigación de Bioquímica y Nutrición “Alberto Guzmán Barrón”. Facultad de Medicina. Universidad Nacional Mayor de San Marcos
  • SALOMÓN AYALA Centro de Investigación de Bioquímica y Nutrición “Alberto Guzmán Barrón”. Facultad de Medicina. Universidad Nacional Mayor de San Marcos
  • RAQUEL ORÉ Centro de Investigación de Bioquímica y Nutrición “Alberto Guzmán Barrón”. Facultad de Medicina. Universidad Nacional Mayor de San Marcos
  • JORGE ARROYO Centro de Investigación de Bioquímica y Nutrición “Alberto Guzmán Barrón”. Facultad de Medicina. Universidad Nacional Mayor de San Marcos

DOI:

https://doi.org/10.15381/anales.v63i4.1505

Keywords:

Gastric mucosa, drug experiment, research

Abstract

OBJECTIVE: To determine if dragon’s blood Croton palanostigma induces gastric mucus secretion as a protective effect. MATERIAL AND METHODS: Adult male albine 200 to 250 g rats were distributed in 4 groups: (I) control with saline solution; (II) gastric croton 0,8 mL/ kg; (III) duodenal croton 0,8 mL/kg; (IV) ranitidine 50 mg/kg; 10 animals in each group. One hour later, pyloric ligation by abdominal laparatomy was performed under ethil ether anestesia and a histamine discharge was done to stimulate secretion. Stomachs were removed and at the glandular portion mucus secretion was measured by modified Corne method expressed as µg of alcian blue/mL/g of tissue. RESULTS: Mucus production by groups was: control 34,5±5,5; gastric croton 45,8±12,2; duodenal croton 50,6±13,9; ranitidine 39,0±7,1. There was significative more mucus production in the gastric and duodenal croton groups than in the control group p<0,01; there was no difference between ranitidine and control groups. Best croton induction was via duodenum, indicating that mechanism is not solely topical, to be confirmed in future studies. CONCLUSIONS: We found induction of gastric mucus production following application of dragon’s blood croton palanostigma via stomach and duodenun and this could be part of the croton’s protection mechanism.

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Published

2002-12-30

Issue

Vol. 63 No. 4 (2002)

Section

Trabajos originales

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Copyright (c) 2002 MIGUEL SANDOVAL, SALOMÓN AYALA, RAQUEL ORÉ, JORGE ARROYO

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How to Cite

1.
SANDOVAL M, AYALA S, ORÉ R, ARROYO J. INDUCTION OF GASTRIC MUCUS BY DRAGON’S BLOOD (Croton palanostigma). An Fac med [Internet]. 2002 Dec. 30 [cited 2024 Jul. 17];63(4):251-6. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1505