Therapeutic effect of Erythroxylum coca spp. ethanol extract in experimental iron-deficiency anemia in male Holtzman rats
DOI:
https://doi.org/10.15381/anales.v74i1.2004Keywords:
Coca, anemia, iron-deficiency, hemoglobin, rats, HoltzmanAbstract
Coca leaf has been traditionally used for medical purposes and contains high iron levels. Objective: To determine the effect of Erythroxylum coca spp. ethanol extract in iron-deficiency anemia induced by iron-deficient diet in male Holtzman rats. Design: Experimental. Setting: Institute of Pathology Laboratory, Universidad Nacional Mayor de San Marcos. Biologic material: Eighteen weaned male Holtzman rats 16 days old. Interventions: Rats were allocated to three groups of six rats each: a) iron-sufficient group (IS) received 25 g/d of balanced diet for 7 weeks; b) iron-deficient group (ID) received 25 g/d of iron-deficient diet for 7 weeks; and, c) irondeficient/ E. coca extract group (ID-CE) received 25 g/d of iron-deficient diet for 7 weeks, and in the fifth week 18 g/d of E. coca extract were added. Main outcome measures: Serum hemoglobin level, weight and height. Results: At the end of the treatment, there was significant difference of hemoglobin in the ID-CE group (p=0.04). There was significant difference in serum hemoglobin levels between ID-CE and ID groups (p=0.0062). No significant difference was found in serum hemoglobin levels between ID-CE and IS groups (p=0.06). No significant difference was found in weight and height between ID and ID-CE groups (p=0.20 and p=0.23, respectively). Conclusions: E. coca had experimental antianemic effect supported by findings in the serum hemoglobin levels.Downloads
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2013-03-18
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Copyright (c) 2013 Evelyn F. Gonzales-Carazas, Giannina C. Melgarejo-García, Lizeth K. Chávez-Conde, Luis J. Arellán-Bravo, Elena Carbajal-Lázaro, Yasmine A. Cabrera-Gómez, Gilmer M. Quiróz-Sáenz, Isis N. García-Antúnez, Miguel Llanto-Aguirre, Franchesca G. Choque-Nolasco
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Gonzales-Carazas EF, Melgarejo-García GC, Chávez-Conde LK, Arellán-Bravo LJ, Carbajal-Lázaro E, Cabrera-Gómez YA, et al. Therapeutic effect of Erythroxylum coca spp. ethanol extract in experimental iron-deficiency anemia in male Holtzman rats. An Fac med [Internet]. 2013 Mar. 18 [cited 2024 Jun. 30];74(1):7-10. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/2004