Insulin resistance in euthyroid women with thyroid nodules: case-control study
DOI:
https://doi.org/10.15381/anales.v82i2.20249Keywords:
Thyroid Nodule, Insulin Resistance, Women, IodineAbstract
Objective. To establish the association between insulin resistance and thyroid nodules in euthyroid women from Metropolitan Lima. Methods. Study in euthyroid women, 20 to 70 years of age: 32 cases (with thyroid nodules) and 32 controls (without thyroid nodules), by ultrasound of the thyroid, negative anti-thyroid antibodies, and adequate urinary iodine excretion (EUI), matched by age and BMI, treated in the Almenara-EsSalud care network. Using a clinical record, age and anthropometric parameters were recorded. Was measured: glucose, basal insulin (IB), and insulin resistance (IR) using the homeostatic model (HOMAIR≥2.97). EUI was detected by spectrophotometer at 420 nm, it was considered adequate between 100-300 ug/L. For the statistical analysis, the student’s t-test, Chi-square test, Fisher’s exact test, and Odds Ratio adjusted for age and abdominal obesity were used, considering a statistically significant p <0.05. Results: Significant differences were observed in the means between the group of cases and controls in fasting glucose, IB, HOMA-IR (4.3 vs 2.5, p <0.05), and EUI levels were lower in the group of cases (167.2 vs 228.3 ug/L p <0.001). IR was more frequent in the case group than in the control group (82.3% vs 28.1%; p <0.001). The Odds Ratio was 14.8 (95% CI: 3.4-65.1). Conclusion: In this study, a significant association was found between the presence of thyroid nodules and insulin resistance in euthyroid adult women residing in an iodine-sufficient region.
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