Type 1 diabetes mellitus and autoimmune cerebellar ataxia with anti-glutamate decarboxylase
DOI:
https://doi.org/10.15381/anales.v85i4.29193Keywords:
Cerebellar Ataxia, Cerebellar Diseases, Paraneoplastic Cerebellar Degeneration, Type 1 Diabetes Mellitus, Autoimmunity, Case ReportsAbstract
The cerebellar ataxia variant associated with antibodies against glutamic acid decarboxylase 65 (GAD-Ab) is associated with type 1 diabetes mellitus (DM). We present the case of a 63-year-old woman with cerebellar ataxia of unknown origin, who was later diagnosed with T1DM. The identification of GAD-Ab in the cerebrospinal fluid (CSF) demonstrated the association between the two conditions. Diagnosis requires demonstration of increased intrathecal synthesis of GAD-Ab. We emphasize the importance of considering GAD-Ab-associated cerebellar ataxia among the causes of cerebellar ataxia to provide timely and effective treatment.
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