Vitamin E supplementation benefits in Hipercholesterolemic rats

Authors

  • Raquel Oré Sifuentes Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Rubén Valdivieso Izquierdo Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Inés Arnao Salas Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Silvia Suarez Cunza Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú

DOI:

https://doi.org/10.15381/anales.v62i1.4117

Keywords:

Atherosclerosis, Vitamin E, Lipid Peroxidation, Research

Abstract

OBJECTIVE: To assess the vitamin E protective effects against free radicals generation, as it is involved in atheroma plate formation. MATERIAL AND METHODS: We used adult Sprague-Dawley rats as experimental models during three months, arranged into four groups: 1) Control diet group; 2) Control diet plus vitamin E (500 mg/Kg of food) group; 3) cholesterol-rich diet (3%) plus vitamin E group, and 4) cholesterol-rich diet group. Lipid profile and lipid peroxidation were measured both in serum and aortic tissue. RESULTS: The cholesterol-rich diet caused a significant increase (p <0,05) in serum triglycerides, and total and LDL cholesterol levels and a significant decrease in HDL cholesterol (p <0,005) levels despite vitamin E (12 mg/day) supplementation. Group IV showed a significant increase (p <0,005) in lipid peroxidation in serum and aortic tissue. CONCLUSIONS: Vitamin E provided protection against both serum and aortic tissue lipid peroxidation but does not improve the lipid profile.
Vol 62, No 1 (2001)

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Published

2001-03-19

Issue

Vol. 62 No. 1 (2001)

Section

Trabajos originales

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Copyright (c) 2001 Raquel Oré Sifuentes, Rubén Valdivieso Izquierdo, Inés Arnao Salas, Silvia Suarez Cunza

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How to Cite

1.
Oré Sifuentes R, Valdivieso Izquierdo R, Arnao Salas I, Suarez Cunza S. Vitamin E supplementation benefits in Hipercholesterolemic rats. An Fac med [Internet]. 2001 Mar. 19 [cited 2024 Jul. 17];62(1):7-12. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4117