The Insuline Analogues

Authors

  • Elizabeth Garrido Carrasco Servicio de Endocrinología, Hospital Nacional Edgardo Rebagliati Martins, Lima, Perú

DOI:

https://doi.org/10.15381/anales.v62i2.4164

Keywords:

Insulin, analogs, Diabetes Mellitus Insulin - Dependent, therapy, Hypoglycemia

Abstract

Insulin analogues are a new pharmaceutical family, designed to overcome deficiencies that still exist with the rDNA insulin. There are rapid-acting insulin analogues such as lispro insulin and insulin aspart. They avoid postprandial and nocturnal hypoglycemia. There are also intermediate-acting insulin analogues like NPL and Mix 25 (a mixture between NPL and lispro), which join the neutral protamine insulin length of action and the fast onset of the rapid-acting analogue lispro. Finally, there is a long-acting analog: glargine, showing a 24-hours action and a peakless profile. In the near future we will have acylated analogues, to get better insulin levels into the liver. This large group of novel patterns of insulin activity provides new options in the treatment of diabetic patients, heading for lower complication risks. The main characteristics, chemical properties and therapeutic applications of each analog were reviewed, because all this drug family is with us nowadays.
Vol 62, No 2 (2001)

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Published

2001-06-18

Issue

Vol. 62 No. 2 (2001)

Section

Artículos de Revisión

License

Copyright (c) 2001 Elizabeth Garrido Carrasco

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How to Cite

1.
Garrido Carrasco E. The Insuline Analogues. An Fac med [Internet]. 2001 Jun. 18 [cited 2024 Jul. 17];62(2):135-50. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4164