Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats

Authors

  • Salomón Ayala Pío Departamento de Ciencias Dinámicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Hilda Jurupe Departamento de Ciencias Dinámicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • David Díaz Instituto de Patología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Olga Lock Facultad de Química, Pontificia Universidad Católica del Perú, Lima, Perú
  • María Vega Departamento de Ciencias Dinámicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Jorge Luque Escuela de Medicina Humana, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Marco Garnique Escuela de Medicina Humana, Universidad Nacional Mayor de San Marcos, Lima, Perú

DOI:

https://doi.org/10.15381/anales.v62i4.4205

Keywords:

Gastric mucosa, Plants, medicinal, Anti-ulcer agents, Disease models, animal

Abstract

OBJECTIVE: The gastric protective abilities of dried sap and alkaloid fraction of Croton palanostigma and sucralfate against ethanol-induced necrosis was compared by means of standard experimental rat model. Subchronic toxicity was determined. MATERIAL AND METHODS: A pretreatment with either saline solution, dried sap of C. palanostigma 120 mg/kg, alkaloid fraction of C. palanostigma 20 mg/kg, 35 mg/kg y 50 mg/kg or sucralfate was given to 60 rats. Intragastric administration of 2 mL of 100% ethanol was accomplished one hour later. A gastrectomy was perfomed four hours later followed by macroscopic and histological evaluation of the gastric lesions. Subchronic toxicity was determined with doses of 0,12, 0,40 and 1,20 mL/kg of sap for a 30-day period with biochemical and histopathologic study of the organs. RESULTS: Pretreatment with dried sap and alkaloid fractions of C. palanostigma and sucralfate resulted in a significant reduction of ethanol-induced gastric mucosa necrosis. Subchronic toxicity with C. palanostigma largest dose showed risk of liver steatosis. CONCLUSION: In the present study, dried sap and alkaloid fraction of C. palanostigma and sucralfate showed a significative protective effect, being potentially useful as a therapeutic tool. Subchronic toxicity in higher doses showed risk of liver steatosis.
Vol 62, No 4 (2001)

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Published

2001-12-31

Issue

Vol. 62 No. 4 (2001)

Section

Trabajos originales

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Copyright (c) 2001 Salomón Ayala Pío, Hilda Jurupe, David Díaz, Olga Lock, María Vega, Jorge Luque, Marco Garnique

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How to Cite

1.
Ayala Pío S, Jurupe H, Díaz D, Lock O, Vega M, Luque J, et al. Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats. An Fac med [Internet]. 2001 Dec. 31 [cited 2024 Jul. 17];62(4):317-24. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4205