Serum Growth Hormone and IGF-I Levels, and Submaximal Exercise at High Altitudes and Sea Level

Authors

  • Angel Pérez Valverde Sección de Fisiología Facultad de Medicina Universidad Nacional Mayor de San Marcos Lima, Perú

DOI:

https://doi.org/10.15381/anales.v60i1.4495

Keywords:

Somatotropin, Insulin-like Growth Factor I, Exertion, Altitude

Abstract

OBJETIVE: To assess serum growth hormone (GH) and insulin-like growth factor I (IGF-I) levels among high altitudes (HA) and sea level (SL) natives, and its variations with exercise. METHODS: 50 young men from Cerro de Pasco (4,340 m) and 40 individuals from Lima (150 m) were evaluated. Each subgroup underwent differentintensity exercise. Pre- and post-exercise hematocrit, hemoglobin, glucose, GH, IGF-I, insulin and glucagon levels were recorded. RESULTS: Baseline GH levels at SL showed no significant differences with those at HA (0,79 ng/mL vs. 0,98 ng/mL; p >0,05), whereas baseline IGF-I levels were higher at SL (299,38 ng/mL vs. 63,71 ng/mL; p <0,01). Among SL natives, there were a significant correlation between baseline GH and IGF-I (r = 0,44) levels. Submaximal exercise results in a significant rise of GH (0,79 to 5,54 ng/mL [r = 0,51] and 0,98 to 8,47 ng/mL [r = 0,51] at HA and SL, respectively) levels. On the other hand, exercise exert no significant variations on insulin, IGF1, glucagon or glucose levels. CONCLUSION: Submaximal exercise at HA and SL could result in high fasting GH levels observed in young adults, but it would not increase IGF-I and glucose levels.

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Published

1999-03-15

Issue

Vol. 60 No. 1 (1999)

Section

Trabajos originales

License

Copyright (c) 1999 Angel Pérez Valverde

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How to Cite

1.
Pérez Valverde A. Serum Growth Hormone and IGF-I Levels, and Submaximal Exercise at High Altitudes and Sea Level. An Fac med [Internet]. 1999 Mar. 15 [cited 2024 Aug. 16];60(1):7-15. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4495