Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats

Authors

  • Salomón Ayala Pío Departamento de Ciencias Dinámicas Facultad de Medicina Universidad Nacional Mayor de San Marcos Lima, Perú
  • David Díaz Instituto de Patología Facultad de Medicina Universidad Nacional Mayor de San Marcos Lima, Perú
  • Manuel Palomino Departamento de Ciencias Dinámicas Facultad de Medicina Universidad Nacional Mayor de San Marcos Lima, Perú
  • Segundo Armas Departamento de Ciencias Dinámicas Facultad de Medicina Universidad Nacional Mayor de San Marcos Lima, Perú
  • Juan Paz Facultad de Medicina Universidad Nacional Mayor de San Marcos Lima, Perú

DOI:

https://doi.org/10.15381/anales.v60i1.4498

Keywords:

Gastric Mucosa, Plants, Medicinal, Anti-Ulcer Agents, Disease Models, Animal

Abstract

OBJECTIVE: The gastric protective abilities of Croton palanostigma (dragonis blood), Aloe vera, sucralfate, and antacid against acute ethanol-induced necrosis by means of a standard experimental model in rats, were compared. MATERIAL AND METHODS: A pretreatment with either saline solution; 0,8 mL/kg or 0,4 mL/kg C. palanostigma; 7,5 mL/kg or 3,2 mL/kg A. vera; 500 mg/kg sucralfate; or antacid was given to 56 fasted rats. Then we accomplished an intragastric administration of 2 mL of 100% ethanol one hour later. A gastrectomy was performed four hours later followed by a macroscopic and histologycal evaluation of the gastric lesions. RESULTS: C. palanostigma pretreatment resulted in a significant reduction of ethanol-induced gastric mucosa Protective effect of Croton palanostigma, Aloe vera, SUCRALFATE AND ANTACID AGAINST ACUTE ETHANOL-INDUCED GASTRIC MUCOSA necrosis. A. vera failed to show mucosal protection. Sucralfate showed a significant protective effect, while antacid exhibited a lesser protective effect. CONCLUSION: In the present study, C. palanostigma showed an important protective effect, being potentially useful as a therapeutic tool.

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Published

1999-03-15

Issue

Vol. 60 No. 1 (1999)

Section

Trabajos originales

License

Copyright (c) 1999 Salomón Ayala Pío, David Díaz, Manuel Palomino, Segundo Armas, Juan Paz

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How to Cite

1.
Ayala Pío S, Díaz D, Palomino M, Armas S, Paz J. Protective Effect of Aloe vera and Croton palanostigma against Acute Gastric Mucosa Injury Induced by Ethanol in Rats. An Fac med [Internet]. 1999 Mar. 15 [cited 2025 Jun. 7];60(1):22-9. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4498