Frequency of p53 Accumulation in Biopsies of Patient with Lung Cancer. Hospital Nacional Guillermo Almenara, 1990 – 1998

Authors

  • Maritza Puray Facultad de Medicina Universidad Nacional Mayor de San Marcos Lima, Perú
  • Yesenia Palomino Facultad de Medicina Universidad Nacional Mayor de San Marcos Lima, Perú

DOI:

https://doi.org/10.15381/anales.v60i1.4500

Keywords:

Protein p53, Biopsy, Lung Neoplasms

Abstract

OBJECTIVE: To determine the frequency of p53 protein accumulation in biopsies of lung cancer patients and to find a correlation between p53 accumulation and patients' age and gender and the differentiation of the tumor. MATERIAL AND METHOD: 201 formalin fixed, paraffin embedded lung tissue sections corresponding to 87 adenocarcinomas, 88 squamous cell carcinomas, 15 large-cell carcinomas, and 11 small-cell carcinomas were retrospectively studied. We have used the labeled streptavidin biotin immunohistochemical method with antibody DO-7, and a microwave pretreatment to recover the antigens. RESULTS: The global frequency of p53 accumulation was 59,7% and the frequency regarding to tumor type was 63,2%, 55,7%, 73,3%, and 45,4%, respectively. CONCLUSION: The protein p53 inversely correlated with the degree of tumor differentiation, but there is no correlation between p53 and patients’ gender neither age.

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Published

1999-03-15

Issue

Vol. 60 No. 1 (1999)

Section

Trabajos originales

License

Copyright (c) 1999 Maritza Puray, Yesenia Palomino

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How to Cite

1.
Puray M, Palomino Y. Frequency of p53 Accumulation in Biopsies of Patient with Lung Cancer. Hospital Nacional Guillermo Almenara, 1990 – 1998. An Fac med [Internet]. 1999 Mar. 15 [cited 2025 Jun. 8];60(1):30-5. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4500