Pancreas Allograft Transplantation in Dogs with Experimental Diabetes Mellitus

Authors

  • Rolando Mendívil Zapata Departamento de Cirugía y Laboratorio Experimental, Hospital Nacional Dos de Mayo, Lima, Perú
  • Fausto Garmendia Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Cecilia Yerén Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • William Torres Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú

DOI:

https://doi.org/10.15381/anales.v59i4.4518

Keywords:

Experimental Diabetes Mellitus, Pancreas Transplant

Abstract

OBJETIVE : To evaluate the efficacy of pancreatic allograft transplantation (TAP ) in dogs with diabetes mellitus ( DME ) induced by alloxan . METHODS : 63 mongrel dogs were used , of which 33 for the very best experimental conditions , the other 30 were divided into 3 groups of 10 each : a) controls, were only produced DME b ) receptors with DME, the who underwent TAP and c) pancreas donors . RESULTS : The glycemic control was complete in 50% of recipients and partial in 30% , giving an overall efficiency of TAP relative to control 80 %. The survival time was 19.9 + TAP post - 6,2 hours. Pathologic examination showed signs of hyperacute rejection , Major complications were gastrointestinal bleeding , aspiration pneumonia , necrotizing pancreatitis with generalized peritonitis , hypoglycemia and dogs not awakened from anesthesia. CONCLUSIONS : The TAP was effective in controlling blood glucose levels in 80 % of animals , but survival was poor, which could be related to the toxic effect of alloxan and hyperacute rejection. More experimental studies are needed to improve survival .

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Published

1998-12-31

Issue

Vol. 59 No. 4 (1998)

Section

Trabajos originales

License

Copyright (c) 1998 Rolando Mendívil Zapata, Fausto Garmendia, Cecilia Yerén, William Torres

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How to Cite

1.
Mendívil Zapata R, Garmendia F, Yerén C, Torres W. Pancreas Allograft Transplantation in Dogs with Experimental Diabetes Mellitus. An Fac med [Internet]. 1998 Dec. 31 [cited 2024 Jul. 18];59(4):267-76. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4518