Observations on the therapeutic and pharmacological actions of fluocortolone

Authors

  • Fausto Garmendia Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Héctor Valdivia Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Desiderio Aguero Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú
  • Norberto Quesada Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú

DOI:

https://doi.org/10.15381/anales.v52i1-2.5100

Abstract

Was performed in 30 patients, a clinical study of the therapeutic and pharmacological effects of the fluocortolone ( Ultralan - ( R ) 1) , novel synthetic steroid derived from corticosterone . As adjunctive treatment of tuberculostatic drugs was administered to 18 patients with different clinical forms of tuberculosis (pleurisy with effusion , meningitis , miliary seeding) , in 6 patients with hypersensitivity reactions , 2 with systemic lupus erythematosus, one with dermotomiositis and 3 with leukemia . It has been seen that fluocortolone possesses a good anti- inflammatory effect with a relatively low potential to cause the appearance of secondary maniIestaciones . On the second day of administration, determinations and 17 - 0HS urinary 17 -KS showed that a single morning dose of 30 mgms . , Fluocortolone has a suppressive effect of somewhat less than 2 mgms adrenal function . dexamethasone are administered as in the test of Liddle . At the end of the third week of a 4 week course of treatment, the average value of the 17 - 0HS descended urinals to constitute 20 % of baseline and 3 days after the suspension thereof be reached 66 %.

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Published

1969-06-16

Issue

Vol. 52 No. 1-2 (1969)

Section

Trabajos originales

License

Copyright (c) 1969 Fausto Garmendia, Héctor Valdivia, Desiderio Aguero, Norberto Quesada

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How to Cite

1.
Garmendia F, Valdivia H, Aguero D, Quesada N. Observations on the therapeutic and pharmacological actions of fluocortolone. An Fac med [Internet]. 1969 Jun. 16 [cited 2024 Jul. 17];52(1-2):10-24. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/5100