Study of the mechanisms of CO2 fixation in Ehrlich ascites tumor

Authors

  • Ernesto Melgar Salmón Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú

DOI:

https://doi.org/10.15381/anales.v45i3-4.5998

Abstract

We conducted the study of the mechanisms of CO2 fixation in the Ehrlich ascites tumor , with the following results : 1. Ribose -5-phosphate was a slight stimulatory effect of fixing C14O2 ; however, could not be isolated 3- phosphoglyceric radioactive conditions that favored its accumulation . Two . Using pyruvic acid as a substrate , the amount of binding was higher . The addition of TPNH to said attachment homogenates greatly increased . Three . Isolates organic acids , the increased incorporation of C14 was detected in the succinic and malic . April . The partially purified acetone extracts showed activity of malic enzyme . The above results allow us to conclude that in the Ehrlich ascites tumor , CO2 fixation is performed almost exclusively by the action of malic enzyme , there being no evidence that it occurs at the level of ribulose -1 ,5- diphosphate.

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Published

1962-12-31

Issue

Vol. 45 No. 3-4 (1962)

Section

Trabajos originales

License

Copyright (c) 1962 Ernesto Melgar Salmón

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How to Cite

1.
Melgar Salmón E. Study of the mechanisms of CO2 fixation in Ehrlich ascites tumor. An Fac med [Internet]. 1962 Dec. 31 [cited 2024 Jul. 4];45(3-4):283-301. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/5998