Effect of Baccharis genistelloides (carqueja) ethanol extract on 1,2-dimethylhydrazine-induced rodent’s colon cancer

Authors

  • Hugo Justil Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos.
  • Jorge Arroyo 1 Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú. 2 Laboratorio de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.
  • José Valencia Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos.

DOI:

https://doi.org/10.15381/anales.v71i2.79

Keywords:

Baccharis, neoplasms, colon, 1, 2-dimethylhydrazine.

Abstract

Introduction: Baccharis genistelloides leaves ethanol extract may reduce gastric cancer development and is an oxidative stress marker. Objectives: To determine the chemoprotector efficacy of Baccharis genistelloides (EEBG) leaves ethanol extract in 1,2-dimethylhydrazine (DMH)-induced colon cancer in male rats. Design: Experimental. Setting: Pharmacology Laboratory, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Carqueja collected in Huancayo, Junin, and 145 + 15 g male rats. Interventions: Intestinal tumors were induced by weekly subcutaneous injection of DMH for 22 weeks at 20 mg/kg. Six groups were formed: Group 1 saline, Group 2 100 mg /kg EEBG; Group 3 DMH; Group 4 DMH plus 100 mg/kg EEBG; Group 5 DMH plus 250 mg/kg EEBG; Group 6 DMH plus 500 mg/kg EEBG. Finally, blood samples were drawn to determine malondialdehyde and nitric oxide level. Main outcome measures: Chemoprotection. Results: Histopathology showed chemoprotection in groups treated with EEBG versus the group without treatment, showing better chemoprotection at 500 mg/kg doses where cancer was poorly differentiated and presenting adenomas, compared with adenocarcinoma in situ and adenocarcinoma respectively at 250 mg/kg and 100 mg/kg doses. Lipoproteins oxidation potential was reduced in groups treated with EEBG compared to those untreated especially with the 500 mg/kg dose; nitric oxide levels also decreased more with 500 mg/kg dose. Conclusions: Baccharis genistelloides ethanol extract has chemoprotective effects on 1,2-dimethylhydrazine-induced rodent’s colon cancer.

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Published

2010-06-14

Issue

Vol. 71 No. 2 (2010)

Section

Trabajos originales

License

Copyright (c) 2010 Hugo Justil, Jorge Arroyo, José Valencia

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How to Cite

1.
Justil H, Arroyo J, Valencia J. Effect of Baccharis genistelloides (carqueja) ethanol extract on 1,2-dimethylhydrazine-induced rodent’s colon cancer. An Fac med [Internet]. 2010 Jun. 14 [cited 2024 Jul. 17];71(2):88-96. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/79