Subclinical atherosclerosis and metabolic profile in middle age asymptomatic women with TSH ≥ 2,5 uUI/mL
DOI:
https://doi.org/10.15381/anales.v73i2.820Keywords:
Receptors/thyrotropin, atherosclerosis, hypothyroidism, glucose metabolism disordersAbstract
Subclinical hypothyroidism may contribute to development of cardiovascular disease and has been shown that TSH >2.5uUI/mL is associated with endothelial dysfunction. Objectives: To determine carotid intima media thickness (CIMT), presence of carotid artery plaque and metabolic profile in asymptomatic middle-aged women with TSH ≥2.5 uUI/mL, and compare them with those with levels <2.5 uUI/mL. Design: Analytical and cross-sectional study. Setting: Dos de Mayo Hospital and Institute of Clinical Research, Universidad Nacional Mayor de San Marcos, Lima, Peru. Participants: Women with no history of thyroid disease, cardiovascular disease or diabetes. Interventions: Total cholesterol, HDL cholesterol, triglycerides, oral glucose tolerance test (OGTT), fasting insulin (F-Ins), body mass index (BMI), waist circumference and blood pressure were assessed in 60 women with no history of thyroid disease, cardiovascular disease or diabetes with mean age 53,8 ± 5,8 years. HOMA-IR index and LDL cholesterol were also determined. CIMT was measured by Doppler ultrasound. Main outcome measures: TSH ≥ 2.5 uUI/mL and metabolic profile, and association with CIMT. Results: From 60 women 38.3% had TSH ≥2.5 and 61.7% TSH <2.5 uUI/mL; 56% of women with TSH ≥2.5 and 65% with TSH <2.5 uUI/mL were hypertensive with no statistical difference. Lipid profile, fasting glucose, F-ins and index HOMA-IR were similar in both groups. Higher levels of BMI, glucose at 120 minutes, left CIMT and maximal CIMT were observed in women with TSH ≥2.5 uUI/mL (p=0.03, p=0.01, p=0.008 and p=0.02 respectively). The presence of plaques in the left carotid artery and in at least one of the carotid arteries was significantly more frequent in women with TSH ≥2.5 uUI/mL. Conclusions: TSH levels ≥2.5 uUI/mL in middle-aged women predispose to altered glucose metabolism and subclinical atherosclerosis.Downloads
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2012-06-18
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Copyright (c) 2012 Rosa M. Pando-Álvarez, Harold L. Torres-Aparcana, Hugo Arbañil-Huamán, Elías Aliaga-Herrera
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Pando-Álvarez RM, Torres-Aparcana HL, Arbañil-Huamán H, Aliaga-Herrera E. Subclinical atherosclerosis and metabolic profile in middle age asymptomatic women with TSH ≥ 2,5 uUI/mL. An Fac med [Internet]. 2012 Jun. 18 [cited 2024 Jul. 17];73(2):107-11. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/820