Carcinoembryonic antigen and recurrence in survival of patients with resection of colorectal cancer

Authors

  • Jorge Renato Cribilleros Barrenechea Departamento de Cirugía General, Servicio de Colon y Recto, Hospital Nacional Rebagliati Martins, EsSalud, Lima, Perú
  • Teófilo Herrera Solís Departamento de Cirugía General, Servicio de Colon y Recto, Hospital Nacional Rebagliati Martins, EsSalud, Lima, Perú
  • Jorge Luis Arroyo Acevedo Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú

DOI:

https://doi.org/10.15381/anales.v75i2.8377

Keywords:

Carcinoembryonic antigen, recurrence, survival

Abstract

Introduction: Carcinoembryonic antigen (CEA) has been associated with advanced stage, poor survival and early detection of recurrent colorectal cancer (CRC). Objectives: To determine relation between serum CEA and recurrence and survival of patients with curative resection of colorectal cancer. Design: Retrospective, correlational and explanatory study. Setting: Department of General and Oncology Surgery, Service of Colon and Rectum, Hospital Nacional Rebagliati Martins, EsSalud, Lima, Peru. Participants: Patients with curative resection of CRC. Methods: Patients with curative resection of CRC at Rebagliati Hospital during years 2000-2003 were followed until 2010. For variables quantitative comparison T test mean differences was used, and Kaplan-Meier method and Cox regression survival analysis techniques were used. Main outcome measures: Patients recurrence and survival. Results: Increased serum CEA in the pre and postoperative periods was related to significant increased recurrence of colorectal cancer (p <0.05). Survival in patients with pathological CEA was significantly lower than in patients with standard CEA (p <0.05). Conclusions: Elevated serum carcinoembryonic antigen was related to increased colorectal cancer recurrence. Serum CEA values in the preoperative period would be predictive of survival.

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Published

2014-06-16

Issue

Vol. 75 No. 2 (2014)

Section

Trabajos originales

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Copyright (c) 2014 Jorge Renato Cribilleros Barrenechea, Teófilo Herrera Solís, Jorge Luis Arroyo Acevedo

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How to Cite

1.
Cribilleros Barrenechea JR, Herrera Solís T, Arroyo Acevedo JL. Carcinoembryonic antigen and recurrence in survival of patients with resection of colorectal cancer. An Fac med [Internet]. 2014 Jun. 16 [cited 2024 Jul. 17];75(2):137-43. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/8377