Satureja brevicalyx ‘wayra muna’ leaves hydroalcoholic extract neuroprotection in a hyperoxia and ischemia-hypoxia animal model

Authors

  • Rody Arias-Rodríguez Escuela de Formación Profesional de Farmacia y Bioquímica, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, Perú
  • Jimmy Pascual Toma-Zárate Escuela de Formación Profesional de Farmacia y Bioquímica, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, Perú
  • Enrique Javier Aguilar-Felices Escuela de Formación Profesional de Farmacia y Bioquímica, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, Perú
  • Emilio Germán Ramírez-Roca Escuela de Formación Profesional de Farmacia y Bioquímica, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, Perú
  • Roberto Shimabuku-Azato Departamento Académico de Pediatría, Universidad Nacional Mayor de San Marcos, Lima. Instituto Nacional de Salud del Niño, Lima, Perú.
  • Silvia Suárez-Cunza Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú.

DOI:

https://doi.org/10.15381/anales.v73i3.867

Keywords:

Neuroprotective agents, oxidative stress, superoxide dismutase, glutathione, hyperoxia, anoxia, satureja.

Abstract

Objectives: To determine Satureja brevicalyx ‘wayra muna’ leaves hydroalcoholic extract neuroprotective effect in rats subjected to hyperoxia and its progeny to hypoxia ischemia. Design: Experimental. Setting: Department of Experimental Surgery, National Institute of Child Health, and Biochemistry and Nutrition Research Center Laboratory, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Rattus novegicus Holtzman strain, Satureja brevicalyx ‘wayra muna’ dry leaves. Interventions: Treatment with the extract had two models: hyperoxia in adult female rats and hypoxia in the offspring of rats treated. Both ANOVA and Tukey test were performed. Main outcome measures: Superoxide dismutase (SOD) activity, total glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels. Results: Rats treated with the extract showed significant decrease in TBARS and participation of GSH and SOD. Conclusions: Our results suggest that Satureja brevicalyx hydroalcoholic extract exerts neuroprotective effect in hyperoxia and hypoxia conditions by alleviating experimental lipid peroxidation, an oxidative damage parameter, with participation of GSH and SOD activity as antioxidant defense mechanisms.

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Published

2012-09-17

Issue

Vol. 73 No. 3 (2012)

Section

Sección Bioquímica y Nutrición

License

Copyright (c) 2012 Rody Arias-Rodríguez, Jimmy Pascual Toma-Zárate, Enrique Javier Aguilar-Felices, Emilio Germán Ramírez-Roca, Roberto Shimabuku-Azato, Silvia Suárez-Cunza

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How to Cite

1.
Arias-Rodríguez R, Pascual Toma-Zárate J, Aguilar-Felices EJ, Ramírez-Roca EG, Shimabuku-Azato R, Suárez-Cunza S. Satureja brevicalyx ‘wayra muna’ leaves hydroalcoholic extract neuroprotection in a hyperoxia and ischemia-hypoxia animal model. An Fac med [Internet]. 2012 Sep. 17 [cited 2024 Jul. 17];73(3):215-9. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/867