Factors associated with non-adherence to highly active antiretroviral treatment in HIV/AIDS patients
DOI:
https://doi.org/10.15381/anales.v70i4.927Keywords:
Adherences, anti-retroviral agents, HIV infections, acquired immunodeficiency syndrome.Abstract
Introduction: Non-adherence to highly active antiretroviral treatment (HAART) is the principal reason of therapeutic failure. Objectives: To determine the prevalence and factors associated with non-adherence to HAART in HIV/AIDS patients. Design: Cross-sectional study. Setting: Infectious diseases service, Arzobispo Loayza National Hospital, a teaching hospital. Participants: HIV-infected patients on treatment with highly active antiretroviral treatment. Interventions: HIV-infected patients on treatment with highly active antiretroviral treatment were invited to complete a constructed questionnaire based on instruments evaluating adherence and associated factors. x2-test and Student’s t test were used to determine association; p-values below 0,05 were considered significant. Association magnitude was measured by OR and 95% confidence intervals. A multivariate logistic regression analysis was performed. Main outcome measures: Non-adherence to highly active antiretroviral treatment. Results: Four hundred and sixty five patients were interviewed, median age 36,8±9,1 years, 64,1% males. Nearly 35,9% of the sample was considered non-adherent. In multivariate analysis, being homosexual/bisexual (OR 3,85, 95%CI 1,98-7,51), having a low health-related quality of life (OR 6,22, 95%CI 3,47-11,13), low social support (OR 5,41, 95%CI 3,17-9,22), not having a permanent residence (OR 3,34, 95%CI 1,93-5,79), having psychological morbidity (OR 2,93, 95%CI 1,78-4,82) and having received treatment for a long time (OR 1,04, 95%CI 1,02-1,07) were independently associated with non-adherence. Conclusions: The prevalence of non-adherence was higher than the previously reported in this hospital, but similar to many studies despite their heterogeneity. Mainly psychosocial factors influenced non-adherence to antiretroviral treatment.Downloads
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2009-12-31
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Copyright (c) 2009 Óscar Alvis, Liz De Coll, Lourdes Chumbimune, Cristina Díaz, Judith Díaz, Mary Reyes
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How to Cite
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Alvis Óscar, De Coll L, Chumbimune L, Díaz C, Díaz J, Reyes M. Factors associated with non-adherence to highly active antiretroviral treatment in HIV/AIDS patients. An Fac med [Internet]. 2009 Dec. 31 [cited 2024 Aug. 16];70(4):266-72. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/927