Adjuvant effect of freeze-dried extract of Passiflora edulis (passion fruit) in reducing blood pressure in patients treated with enalapril
DOI:
https://doi.org/10.15381/anales.v70i2.957Keywords:
Passiflora, blood pressure, hypertension.Abstract
Objectives: To determine the adjunctive antihypertensive effect and safety of passion fruit juice in patients with hypertension treated with enalapril. Design: prospective pilot clinical trial, phase II, randomized, double blind, parallel group, controlled, dose finding and evaluation of the product. Setiing: Instituto de Investigaciones Clínicas, Facultad de Medicina, UNMSM, Dos de Mayo Hospital in Lima, Hospital Belen de Trujillo and Moche and Laredo Health Centers in Trujillo city. Participants: Patients with arterial hypertension. Interventions: Patients were randomly assigned to four groups, each receiving enalapril 10 mg / day; the first group also received placebo and the other, 2, 3 and 4 groups, 500 mg capsules of freeze-dried passion fruit juice / day, respectively. Main outcome measures: Reduction in blood pressure. Results: Groups receiving enalapril and passion fruit had better reduction in blood pressure compared with the group receiving enalapril plus placebo. The group treated with enalapril plus 4 capsules of freezedried passion fruit juice / day had a reduction in systolic blood pressure of 6,73 mmHg and diastolic blood pressure of 5,33 mmHg (p<0,05) compared with the enalapril group more placebo. No adverse effects were observed. Conclusions: P. edulis juice fruit was effective adjuvant to enalapril in reducing blood pressure in patients with stage 1 hypertension, with proved safety
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2009-06-15
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Copyright (c) 2009 Juan Rojas, Sergio Ronceros, Robert Palomino, Marcia Salas, Rubén Azañero, Hernán Cruz, Agustín Rojas, Jorge Asmat, Juan Tam
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Rojas J, Ronceros S, Palomino R, Salas M, Azañero R, Cruz H, et al. Adjuvant effect of freeze-dried extract of Passiflora edulis (passion fruit) in reducing blood pressure in patients treated with enalapril. An Fac med [Internet]. 2009 Jun. 15 [cited 2024 Aug. 16];70(2):103-8. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/957
