Air pollution and prothrombotic state

Authors

  • Jorge Campos Tecnólogo médico, Magíster(c). Programa de Magíster en Ciencias Biomédicas. Facultad de Ciencias de la Salud, Universidad de Talca, Chile.
  • Iván Palomo Tecnólogo médico, Doctor. Programa de Investigación en Factores de Riesgo de Enfermedad Cardiovascular (PIFRECV), Depto. de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, Chile

DOI:

https://doi.org/10.15381/anales.v70i1.985

Keywords:

Air pollution, coagulation agents, blood platelets, prothrombin, cardiovascular diseases.

Abstract

Air pollution is a heterogenic mixture of gases, liquids and particulate matter (PM) present in the urban modern world. PM rates vary in size from a few nanometers to 10 micra diameter. The exposure to PM is associated to a major risk of cardiovascular diseases as explained by three mechanisms: induction of systemic inflammation and/or oxidative stress, alteration in the cardiac autonomic balance and direct action on the circulatory system, causing acute vasoconstriction, endothelial dysfunction and prothrombotic state. There is evidence suggesting that air pollution is associated with shortened prothrombine time, decrease in tissue plasminogen activator, increase of fibrinogen, factor VIII and factor von Willebrand, and platelet hyperactivity.

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Published

2009-03-16

Issue

Vol. 70 No. 1 (2009)

Section

Temas de revisión

License

Copyright (c) 2009 Jorge Campos, Iván Palomo

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How to Cite

1.
Campos J, Palomo I. Air pollution and prothrombotic state. An Fac med [Internet]. 2009 Mar. 16 [cited 2024 Jul. 17];70(1):41-4. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/985