Hodgkin’s lymphoma with lymphocyte depletion and diffuse bone marrow infiltration

Authors

  • Fernando Carballo Servicio de Medicina, Hospital Dos de Mayo, Lima, Perú
  • Rubén López Jefe, Sala de Medicina San Pedro, Hospital Nacional Dos de Mayo, Lima, Perú
  • Victor Mechán Servicio de Hematología Clínica, Hospital Nacional Dos de Mayo, Lima, Perú
  • Luis Vilchez Servicio de Medicina, Hospital Dos de Mayo, Lima, Perú

DOI:

https://doi.org/10.15381/anales.v72i2.995

Keywords:

Hodgkin lymphoma with lymphocytic depletion, lymphoproliferative syndrome, Reed Sternberg cells, EBV Epstein-Barr virus.

Abstract

We present the case of a 38 year-old male, farmer, born in Lamas, San Martin (Peruvian jungle), who for the past 8 months suffered of diarrhea, intermittent fever, abdominal pain, weight loss and severe anemia. On admission the patient was lucid and exhibited malaise, pallor and generalized lymphadenopathy (size less than 0.5 cm) hepatosplenomegaly and abdominal displaceable dullness. Abdominal computed tomography showed hepatosplenomegaly and retroperitoneal, mesenteric and other adenopathies. Node biopsy revealed Reed-Sternberg cells, mononuclear cells, eosinophiles and scarce lymphocytes. Immunohistochemical node staining was positive for CD15 and CD30 antibodies. Bone biopsy showed diffuse fibrosis, mononuclear cells and scarcity of lymphocytes. In situ hybridization for EBV Epstein Barr virus was positive in neoplastic cells.

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Published

2011-06-13

Issue

Vol. 72 No. 2 (2011)

Section

Casos clínicos

License

Copyright (c) 2011 Fernando Carballo, Rubén López, Victor Mechán, Luis Vilchez

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How to Cite

1.
Carballo F, López R, Mechán V, Vilchez L. Hodgkin’s lymphoma with lymphocyte depletion and diffuse bone marrow infiltration. An Fac med [Internet]. 2011 Jun. 13 [cited 2024 Jul. 3];72(2):137-40. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/995