Association between apolipoprotein E (ApoE) genetic polymorphism and Parkinson’s disease

Authors

  • Victoria Marca Servicio y Centro de Investigación Básica en Neurogenética, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
  • Oscar Acosta Laboratorio de Biología Molecular, Facultad de Farmacia y Bioquímica, UNMSM, Lima, Perú.
  • Luis Torres Unidad de Movimientos Anormales, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
  • Olimpio Ortega Servicio y Centro de Investigación Básica en Neurogenética, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
  • Mario Cornejo-Olivas Servicio y Centro de Investigación Básica en Neurogenética, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. International Northern Global Health Research Fellows Consortium.
  • Saúl Lindo-Samanamud Servicio y Centro de Investigación Básica en Neurogenética, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
  • Doris Huerta Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, UNMSM, Lima, .
  • Carlos Cosentino Unidad de Movimientos Anormales, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. Facultad de Medicina, Universidad Nacional Mayor de San Marcos.
  • Oscar Núñez Servicio y Centro de Investigación Básica en Neurogenética, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
  • Pilar Mazzetti Servicio y Centro de Investigación Básica en Neurogenética, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. Facultad de Medicina, Universidad Nacional Mayor de San Marcos.

DOI:

https://doi.org/10.15381/anales.v74i3.2629

Keywords:

Parkinson's disease, alleles, apolipoprotein E.

Abstract

Due to the increase in life expectancy in our country, it is necessary to study risk factors for Parkinson’s disease (PD), including apolipoprotein E (ApoE) gene, as this association is not known in our country. Objectives: To determine association of ApoE gene polymorphism and PD. Design: Associative, observational case-control analytic study. Setting: Instituto Nacional de Ciencias Neurologicas, Lima, Peru. Participants: Male and females with and without Parkinson's disease. Interventions: Genomic DNA was extracted from 163 patients and 176 controls. PCR_RFLP technique was used for ApoE gene genotyping. Main outcome measures: ApoE gene genotype and allele frequencies in cases and controls, association and risk. Results: No significant ApoE genotype differences between the control group and patients were found. Allele ε4 frequency was similar in patients and controls: 6.5 and 6.0. Odds ratio for ApoE ε4 allele associated with PD was 1.2163 (IC 95%, 0.6574-2.2507). Conclusions: ApoE ε4 allele could not be considered a risk factor for PD in the population studied.

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Published

2013-10-15

Issue

Vol. 74 No. 3 (2013)

Section

Trabajos originales

License

Copyright (c) 2013 Victoria Marca, Oscar Acosta, Luis Torres, Olimpio Ortega, Mario Cornejo-Olivas, Saúl Lindo-Samanamud, Doris Huerta, Carlos Cosentino, Oscar Núñez, Pilar Mazzetti

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How to Cite

1.
Marca V, Acosta O, Torres L, Ortega O, Cornejo-Olivas M, Lindo-Samanamud S, et al. Association between apolipoprotein E (ApoE) genetic polymorphism and Parkinson’s disease. An Fac med [Internet]. 2013 Oct. 15 [cited 2024 Jul. 17];74(3):169-73. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/2629