Interposition of peritoneal segment for the formation of intestinal neomucosa. Experimental study

Abstract

Introduction. Short bowel syndrome is a complex entity that can be the result of both the physical loss of segments of the small intestine and a functional loss which causes a clinical picture of serious metabolic and nutritional alterations due to the reduction of the absorptive surface effective intestinal. Taking into account that the various techniques used for the treatment of short bowel syndrome do not constitute a definitive solution to this problem, we present a peritoneal segment interposition method for the formation of intestinal neomucosa, carried out experimentally and whose objective is to increase the surface intestinal absorptive. Objective. Verify the growth of intestinal neomucosa in the peritoneal segment interposed in the small intestine. Methods. Experimental, prospective and controlled study. The procedure of placing a 1.5 cm patch was carried out in the antimesenteric border of the jejunum of 15 rabbits, which was extracted after 30 days for histopathological study. Results. All animals tolerated and survived the procedure. The microscopic study considered the morphological parameters of the histological evaluation of the intestinal segment to which the peritoneal patch was implanted. The percentage of epithelialization at 30 days is 75-90%. Of the 10 rabbits, 70% presented mild granulation tissue, 20% moderate and 10% severe. Conclusions. The interposition of a patch of peritoneum and autologous abdominal wall is capable of re-epithelializing with intestinal mucosa and expanding the intestinal absorptive surface. In the autologous peritoneal tissue patch, neomucosa growth approaches 90% 30 days after its evolution.