Diagnosis of an emerging Nocardia species infection by MALDI-TOF in a patient with tuberculosis
DOI:
https://doi.org/10.15381/anales.v85i4.29147Keywords:
Nocardia, Mycobacterium tuberculosis, Polymerase Chain Reaction, Spectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAbstract
Nocardia infections exhibit diverse clinical manifestations, pulmonary nocardiosis (PN) is the most common. In countries with a high burden of MDR TB such as Peru, co-infection with Nocardia is possible. We report the case of a 91-year-old male with cough, malaise, and weight loss, initially treated for pulmonary tuberculosis (sputum BK positive) without improvement. Subsequent testing with MALDI-TOF identified Nocardia cyriacigeorgica in sputum, confirming coinfection with Mycobacterium tuberculosis sensitive to rifampin detected through real-time PCR. Rapid diagnostic tools such as PCR and MALDI-TOF enhance diagnostic precision; however, their interpretation must consider individual risk factors to avoid overtreatment and ensure an appropriate therapeutic regimen.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Anales de la Facultad de Medicina
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Those authors who have publications with this magazine accept the following terms:
- Authors will retain their copyrights and guarantee the journal the right of first publication of their work, which will be simultaneously subject to Creative Commons Attribution License that allows third parties to share the work as long as its author and its first publication this magazine are indicated.
- Authors may adopt other non-exclusive licensing agreements for the distribution of the version of the published work (eg, deposit it in an institutional electronic file or publish it in a monographic volume) provided that the initial publication in this magazine is indicated.
- Authors are allowed and recommended to disseminate their work over the Internet (eg: in institutional telematic archives or on their website) before and during the submission process, which It can produce interesting exchanges and increase quotes from the published work. (See El efecto del acceso abierto ).
