Immunohistochemical Markers in Melanocytic Cutaneal Lesions: Reliability of HMB-45 and S-100 Antigens and p53 Protein

Authors

  • Carlos Barrionuevo Instituto Nacional de Enfermedades Neoplásicas Lima, Perú
  • Violeta Seminario Instituto de Patología Universidad Nacional Mayor de San Marcos Lima, Perú
  • Rosa Maita Instituto de Patología Universidad Nacional Mayor de San Marcos Lima, Perú
  • Rubén Rosas Instituto de Patología Universidad Nacional Mayor de San Marcos Lima, Perú
  • Delia Jara Instituto de Patología Universidad Nacional Mayor de San Marcos Lima, Perú
  • John Victorio Instituto de Patología Universidad Nacional Mayor de San Marcos Lima, Perú
  • Isabel Escalante Instituto de Patología Universidad Nacional Mayor de San Marcos Lima, Perú

DOI:

https://doi.org/10.15381/anales.v60i4.4384

Keywords:

Melanoma, Immunohistochemistry, Tumor Markers, Biological, Nerve Tissue Protein S100, Chromogranins, Protein p53

Abstract

OBJECTIVES: To determine the clinicopathological features of patients with cutaneous melanoma, the role of Merckel cells in this tumour and diagnostic usefulness of celular markers. MATERIAL AND METHODS: Clinico-pathological correlation of 650 clinical records of patients with histopathological diagnosis of cutaneous melanoma was done. The Ag S100, HMB-45, cromogranin A, and p53 protein presence were assessed in 30 of these patients who also had pigmented benign skin lesions. RESULTS: Patients with melanoma had history of sunlight exposure and previous nevus or associated nevus. AgS100 was the more sensitive marker but had lesser specificity; HMB-45 was positive in lesions with malignant and active melanocytes whereas p53 was seen in certain melanoma cells. Proliferating Merckel cells were not found. CONCLUSIONS: S100 antigen must be used as diagnostic tool; HMB-45 had a lesser sensitivity. Melanomas, displasic nevus cells and sunlight dermatosis queratinocites were all p53-positive.

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Published

1999-12-31

Issue

Vol. 60 No. 4 (1999)

Section

Trabajos originales

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Copyright (c) 1999 Carlos Barrionuevo, Violeta Seminario, Rosa Maita, Rubén Rosas, Delia Jara, John Victorio, Isabel Escalante

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How to Cite

1.
Barrionuevo C, Seminario V, Maita R, Rosas R, Jara D, Victorio J, et al. Immunohistochemical Markers in Melanocytic Cutaneal Lesions: Reliability of HMB-45 and S-100 Antigens and p53 Protein. An Fac med [Internet]. 1999 Dec. 31 [cited 2024 Jul. 17];60(4):257-64. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4384