Esophageal Stenosis due to Exogenous Chemical Injury
DOI:
https://doi.org/10.15381/anales.v46i4.5846Abstract
Erosive esophagitis in 34 dogs was produced by instillation transesofagoscópica commercial bleach or sodium hydroxide solutions and existing lesions at 13, 21 and 30 days duration was studied. In 8 animals the spontaneous evolution of corrosívcs esophageal lesions , verifying abundance of young fibroblasts , incipient fibrosis and occlusive vascular lesions to the second week of aggression was analyzed. Between 21 and 35 days fibrosis had been outstanding . 14 dogs were divided into three subqrupos and violated with sodium hydroxide solutions of increasing concentrations ( 2.5 N, 5 N and 10 N ) . The immediate mortality was very high in all three subqrupos . The severity of the inflicted damage increased as a direct function of the concentration of the corrosive agent , showing that any clinical or therapeutic assessment should consider the influence of this factor . No favorable effect of parenteral chymotrypsin was observed in the group of animals subjected to the previous experience. Intramuscular administration of adrenocorticotropic hormone to 9 animals allowed to observe rapid attenuation of dysphagia and the healing process , without stenosis removed . Moreover, this group recorded the largest number of micro - perforations and abscesses of the etched walls. ACTH action was similar to that described for the adrenocortical hormones.Downloads
Published
1963-12-30
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Copyright (c) 1963 Rodrigo Ubilluz Dhaga del Castillo
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1.
Ubilluz Dhaga del Castillo R. Esophageal Stenosis due to Exogenous Chemical Injury. An Fac med [Internet]. 1963 Dec. 30 [cited 2024 Jul. 17];46(4):485-513. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/5846