Insulin resistance in obese adolescents

Authors

  • Maria Isabel Rojas-Gabulli 1 Servicio de Endocrinología, Instituto Nacional de Salud del Niño. Lima, Perú. 2 Facultad de Medicina, Universidad Nacional Federico Villarreal. Lima, Perú.
  • Oswaldo Núñez 1 Servicio de Endocrinología, Instituto Nacional de Salud del Niño. Lima, Perú. 2 Facultad de Medicina, Universidad Nacional Federico Villarreal. Lima, Perú.
  • Carlos Del Águila 1 Servicio de Endocrinología, Instituto Nacional de Salud del Niño. Lima, Perú. 2 Facultad de Medicina, Universidad Nacional Federico Villarreal. Lima, Perú.
  • Mariel Briceño Servicio de Endocrinología, Instituto Nacional de Salud del Niño. Lima, Perú.
  • Nelly Valenzuela Facultad de Medicina, Universidad Nacional Federico Villarreal. Lima, Perú.

DOI:

https://doi.org/10.15381/anales.v71i1.66

Keywords:

Obesity, insulin resistance, public health.

Abstract

Introduction: Obesity in children and adolescents is a public health problem that is increasing worldwide, being known its relation with the development of metabolic alterations like diabetes mellitus type 2. Objectives: To determine the presence of insulin resistance in obese and non obese adolescents according to sex, age, pubertal stage and presence of familial metabolic or cardiovascular disorders. Design: Cross-sectional observational and analytical study. Setting: Three Lima urban educational centers. Participants: Adolescents 10 to 17 year-old. Interventions: Sixty nine adolescents between 10 and 17 years old were divided in two groups according to the presence of obesity. Obesity was defined as body mass index >95th percentile, 55,1% were male and 44,9% female. Homeostatic model assessment was employed to determine insulin resistance (HOMA-IR) and beta cell function (HOMA%B) in both groups. Lipid levels were measured by the enzymatic method and a questionnaire was applied to determine familial obesity, diabetes mellitus and cardiovascular disease. Spearman correlation and U Mann-Whitney for media comparison tests were employed. Main outcome measures: Basal insuline, total cholesterol, triglicerids, CLDL cholesterol, HOMA IR and HOMA%B in obese and non obese adolescents. Results: Basal insulin, cholesterol, triglycerides, VLDL cholesterol, HOMA IR and HOMA%B were significantly higher (p<0,05) in the obese group. HOMA –IR showed a weak inverse correlation with Tanner stage in females. Cardiovascular disease and obesity predominated in the obese group families (71,8%). Conclusions: The use of HOMA along with familial disorders identification in obese adolescents is recommended in order to incorporate them in a healthy lifestyle program.

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Published

2010-03-15

Issue

Vol. 71 No. 1 (2010)

Section

Trabajos originales

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Copyright (c) 2010 Maria Isabel Rojas-Gabulli, Oswaldo Núñez, Carlos Del Águila, Mariel Briceño, Nelly Valenzuela

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How to Cite

1.
Rojas-Gabulli MI, Núñez O, Del Águila C, Briceño M, Valenzuela N. Insulin resistance in obese adolescents. An Fac med [Internet]. 2010 Mar. 15 [cited 2024 Jul. 17];71(1):13-7. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/66