Validity of both adenosine deaminase test and differential cell count for pleural tuberculosis diagnosis

Authors

  • Jhonatan Boris Quiñones-Silva 1 Facultad de Medicina Humana, Universidad Nacional José Faustino Sánchez Carrión. Huacho, Perú. 2 Sociedad Científica Huachana de Estudiantes de Medicina. Huacho, Perú.
  • César Héctor Gonzalo Ramírez-Yépez 1 Facultad de Medicina Humana, Universidad Nacional José Faustino Sánchez Carrión. Huacho, Perú. 2 Sociedad Científica Huachana de Estudiantes de Medicina. Huacho, Perú.
  • Américo Peña-Oscuvilca 1 Facultad de Medicina Humana, Universidad Nacional José Faustino Sánchez Carrión. Huacho, Perú. 2 Sociedad Científica Huachana de Estudiantes de Medicina. Huacho, Perú.
  • Efraín Estrada-Choque 1 Facultad de Medicina Humana, Universidad Nacional José Faustino Sánchez Carrión. Huacho, Perú. 2 Hospital Gustavo Lanatta Luján, Ministerio de Salud. Huacho, Perú.

DOI:

https://doi.org/10.15381/anales.v71i1.67

Keywords:

Tuberculosis, pleural, adenosine deaminase, leukocyte count.

Abstract

Objective: To determine the validity of both adenosine diaminase (ADA) test and differential cell count for pleural tuberculosis diagnosis. Design: Retrospective study for diagnosis precision. Setting: Huacho Hospital, Ministerio de Salud, Huacho, Peru. Material: Medical records of patients with ADA test in pleural fluid. Interventions: Medical records study of patients with ADA test in pleural effusion performed from January 2005 through December 2007. ADA test values and differential cell counts were analyzed by ROC curve. Sensitivity (Se), specificity (Sp), predictive values (VPP and VPN) and likehood ratios (LRP and LRN) were found for each variable. Main outcome measures: ADA test cut-off point for pleural tuberculosis diagnosis. Results: Tuberculosis was responsible for most cases of pleural effusion; 47,5 UI/L was the cut-off point by ROC curve, with Se and Sp 73% and 90%, respectively (IC 95%: 0,74 - 0,95; p<0,001). The ROC curve for differential cell count cut-off point was 0,725, with Se and Sp 60,9 and 64,7, respectively (IC 95%: 0,47 - 0,79; p=0,129). Conclusions: The best cut-off point for pleural tuberculosis diagnosis was 47,5 UI/L. This test worked better to confirm the disease rather than ruling it out. Thus, a larger percentage of lymphocytes in the differential cell count (>72%) will increase the suspicious of pleural tuberculosis.

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Published

2010-03-15

Issue

Vol. 71 No. 1 (2010)

Section

Trabajos originales

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Copyright (c) 2010 Jhonatan Boris Quiñones-Silva, César Héctor Gonzalo Ramírez-Yépez, Américo Peña-Oscuvilca, Efraín Estrada-Choque

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How to Cite

1.
Quiñones-Silva JB, Ramírez-Yépez CHG, Peña-Oscuvilca A, Estrada-Choque E. Validity of both adenosine deaminase test and differential cell count for pleural tuberculosis diagnosis. An Fac med [Internet]. 2010 Mar. 15 [cited 2024 Jul. 17];71(1):18-22. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/67