Neurofibromatosis type 1 associated to cognition deficit, hydrocephaly, bone dysplasia and elephantiasis

Authors

  • Julio Ramírez Docente de la Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú. Servicio de Medicina Interna, Hospital Nacional Dos de Mayo. Lima, Perú.
  • Gustavo Wong Servicio de Neurología, Hospital Nacional Dos de Mayo. Lima, Perú.
  • Victor Mechán Docente de la Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú. Servicio de Hematología, Hospital Nacional Dos de Mayo. Lima, Perú.
  • Cesar Durán Servicio de Oftalmología, Hospital Nacional Dos de Mayo. Lima, Perú.
  • Gustavo Cerrillo Servicio de Anatomía Patológica, Hospital Nacional Dos de Mayo. Lima, Perú.
  • Gerardo Ronceros Departamento de Patología Clínica, Hospital Nacional Dos de Mayo. Lima, Perú. Instituto de Investigaciones Clinicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, P
  • Isabel Ballena Servicio de Radiología, Hospital Nacional Dos de Mayo. Lima, Perú.
  • Miguel Llanos Alumno del 5° Año de la Escuela Académico Profesional de Medicina, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.

DOI:

https://doi.org/10.15381/anales.v70i3.941

Keywords:

Neurofibromatosis 1, hydrocephalus, cognition disorders, bone dysplasia, elephantiasis.

Abstract

We report the case of a 31 year-old male from Cajamarca, Peru, with cognitive problems since childhood, who at 12 year-old developed increased volume and deformation of his right lower limb and to a lesser extent of his left, associated to massive skin folding, growth of subcutaneous nodules, elephantine look due to nerve cords formation in thigh and leg, pain and functional walking limitation. Concomitantly generalized skin café au lait spots, subcutaneous nodules, and Lisch nodules in both irides. Magnetic resonance and contrast TAC revealed abundant uniform plexiform nodules in abdomino-pelvic cavity forming masses and cords that continued throughout his thigh as lumps and cords. In addition, the patient presented bone dysplasia (thinning of femur and tibia cortex, pseudoarthrosis, new left cotyle formation). Contrast magnetic resonance showed triventricular normotensive hydrocephalus.

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Published

2009-09-14

Issue

Vol. 70 No. 3 (2009)

Section

Casos clínicos

License

Copyright (c) 2009 Julio Ramírez, Gustavo Wong, Victor Mechán, Cesar Durán, Gustavo Cerrillo, Gerardo Ronceros, Isabel Ballena, Miguel Llanos

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How to Cite

1.
Ramírez J, Wong G, Mechán V, Durán C, Cerrillo G, Ronceros G, et al. Neurofibromatosis type 1 associated to cognition deficit, hydrocephaly, bone dysplasia and elephantiasis. An Fac med [Internet]. 2009 Sep. 14 [cited 2024 Jul. 17];70(3):205-10. Available from: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/941